U6881
U-73343
동의어(들):
1-[6-[((17β)-3-Methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]-2,5-pyrrolidinedione
로그인조직 및 계약 가격 보기
크기 선택
1 MG
₩264,002
5 MG
₩460,100
모든 사진(1)
크기 선택
보기 변경
1 MG
₩264,002
5 MG
₩460,100
About This Item
실험식(Hill 표기법):
C29H42N2O3
CAS Number:
Molecular Weight:
466.66
MDL number:
UNSPSC 코드:
41106300
PubChem Substance ID:
NACRES:
NA.77
추천 제품
분석
≥98% (HPLC)
양식
powder
색상
white
solubility
DMSO: soluble
SMILES string
[H][C@]12CC[C@]3(C)[C@H](CC[C@@]3([H])[C@]1([H])CCc4cc(OC)ccc24)NCCCCCCN5C(=O)CCC5=O
InChI
1S/C29H42N2O3/c1-29-16-15-23-22-10-8-21(34-2)19-20(22)7-9-24(23)25(29)11-12-26(29)30-17-5-3-4-6-18-31-27(32)13-14-28(31)33/h8,10,19,23-26,30H,3-7,9,11-18H2,1-2H3/t23-,24-,25+,26+,29+/m1/s1
InChI key
CJHWFIUASFBCKN-ZRJUGLEFSA-N
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일반 설명
U-73343 is used to assess the involvement of G protein-coupled 1-phosphatidylinositol-phosphodiesterase or phospholipase C in receptor-mediated cell activation. It functions downstream of phospholipase C to block receptor-mediated phospholipase D activation.[1]
애플리케이션
U-73343 has been used for studying the role of phospholipase C (PLC) signaling in modulating epithelial Na+ channel (ENaC) function in gerbil Reissner′s membranes (RMs)[2]. U-73343 has also been used as a negative control for PLC inhibition in mechanically stimulated (MS) and its neighboring (NB) cells[3].
U-73343 has been used in measuring the fluorescence of intracellular Ca2+.[4]
생화학적/생리학적 작용
Inactive analog of U73122; used as a negative control.
제조 메모
U-73343 is soluble in chloroform at 10 mg/ml and yields a clear, colorless to faint yellow solution. It is also soluble in ethanol (0.93 mg/ml) and DMSO (2.3 mg/ml), but is insoluble in water.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
Ayako Kataoka et al.
Journal of neurochemistry, 108(1), 115-125 (2008-11-19)
Microglia are implicated as a source of diverse proinflammatory factors in the CNS. Extracellular nucleotides are well known to be potent activators of glial cells and trigger the release of cytokines from microglia through purinergic receptors. However, little is known
Jue-Long Wang et al.
Toxicology letters, 160(1), 76-83 (2005-07-20)
The effect of the environmental toxicant nonylphenol on cytosolic free Ca2+ concentration ([Ca2+]i) and proliferation has not been explored in human osteoblast-like cells. This study examined whether nonylphenol alters Ca2+ levels and causes cell death in MG63 human osteosarcoma cells.
R J Smith et al.
The Journal of pharmacology and experimental therapeutics, 253(2), 688-697 (1990-05-01)
1-[6-[[17 beta-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]- 1H-pyrrole-2,5-dione (U-73122), an inhibitor of phospholipase C (PLC)-dependent processes in human platelets, was found to be a potent inhibitor of human polymorphonuclear neutrophil (PMN) activation by structurally unrelated receptor-specific agonists. U-73122 caused a time- and concentration-dependent (0.1-1 microM)
Shou-Yuan Zhuang et al.
Neuropharmacology, 48(8), 1086-1096 (2005-05-25)
Exogenously administered cannabinoids are neuroprotective in several different cellular and animal models. In the current study, two cannabinoid CB1 receptor ligands (WIN 55,212-2, CP 55,940) markedly reduced hippocampal cell death, in a time-dependent manner, in cultured neurons subjected to high
U73122 and U73343 inhibit receptor-mediated phospholipase D activation downstream of phospholipase C in CHO cells
Bosch RR, et al.
European Journal of Pharmacology, 346(2-3), 345-351 (1998)
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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