L9908

LY-294,002 hydrochloride

from microbial (Staphylococcus roseus), ≥98% (HPLC), solid, PI3K inhibitor

• 동의어(들): 2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride
• 실험식(Hill 표기법): C₁₉H₁₇NO₃ · HCl
• CAS Number: 934389-88-5
• Molecular Weight: 343.80
• MDL number: MFCD00270881
• UNSPSC 코드: 12352207
• PubChem Substance ID: 24278828
• NACRES: NA.77

속성

• 제품명: LY-294,002 hydrochloride, solid, ≥98% (HPLC)
• 생물학적 소스: microbial (Staphylococcus roseus)
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 색상: white to off-white
• solubility: DMSO: >5 mg/mL; H₂O: insoluble
• 저장 온도: 2-8°C
• SMILES string: O=C1C=C(Oc2c1cccc2-c3ccccc3)N4CCOCC4
• InChI: 1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
• InChI key: CZQHHVNHHHRRDU-UHFFFAOYSA-N

설명

일반 설명

LY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K).[1] LY-294,002 inhibits nuclear factor kappa B signaling in macrophages.[2] It elevates expression of autophagosomal protein LC3 and promotes apoptosis in gastric[3] and nasopharyngeal cancer cells.[4] LY-294,002 modulates action potential repolarization and improves myocyte contractility.[5]

애플리케이션

LY-294,002 hydrochloride has been used in the inhibition of:

• phosphoinositide 3-kinase (PI3K) in human lung cancer cell line[6]
• autophagy in mesenchymal stem cells (MSCs).[7]
• serine/threonine-specific protein kinase (AKT) signaling in fibroblasts[8] and cardiac cells.[9]

생화학적/생리학적 작용

Specific cell permeable phosphatidylinositol 3-kinase inhibitor.

특징 및 장점

This compound is a featured product for Cyclic Nucleotide and Kinase Phosphatase Biology research. Discover more featured Cyclic Nucleotide and Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the G Proteins (Heterotrimeric) and Phosphoinositide Kinases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)