A9789

Anisomycin

from Streptomyces griseolus, ≥98% (HPLC), solid, protein synthesis inhibitor

• 동의어(들): (2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate, 2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate, Flagecidin
• 실험식(Hill 표기법): C₁₄H₁₉NO₄
• CAS Number: 22862-76-6
• Molecular Weight: 265.30
• Beilstein: 20705
• EC Number: 245-269-7
• MDL number: MFCD00077650
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24891496
• NACRES: NA.77

속성

• 제품명: Anisomycin from Streptomyces griseolus, ≥98% (HPLC), solid
• Quality Level: 300
• 분석: ≥98% (HPLC)
• 양식: solid
• 색상: white to faint yellow
• solubility: H₂O: 2 mg/mL (Aqueous solutions are stable over a wide range of pH at room temperature.); DMSO: 20 mg/mL; methanol: 20 mg/mL
• 항생제 활성 스펙트럼: neoplastics
• 동작 모드: protein synthesis | interferes
• 저장 온도: 2-8°C
• SMILES string: COc1ccc(C[C@H]2NC[C@H](O)[C@H]2OC(C)=O)cc1
• InChI: 1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m1/s1
• InChI key: YKJYKKNCCRKFSL-RDBSUJKOSA-N

설명

생화학적/생리학적 작용

Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes.

Antibiotic isolated from Streptomyces griseolus that inhibits protein synthesis. Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. Reported to induce apoptosis in a variety of cells including promyelocytic leukemia cells, Jurkat cells, ventricular myocytes, and colon adenocarcinoma cells. Initiates intracellular signals and immediate early gene induction. Selective signaling agonist. Potent Jun-NH₂ terminal kinase (JNK) agonist. Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK). Antiprotozoal agent.

주의사항

Hygroscopic

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301
• 예방조치 성명서: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges