T1775

L-Thyroxine

powder, BioReagent, suitable for cell culture

• 동의어(들): 3,3′,5,5″-Tetraiodo-L-thyronine, 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine, T₄
• Linear Formula: HOC₆H₂(I)₂OC₆H₂(I)₂CH₂CH(NH₂)CO₂H
• CAS Number: 51-48-9
• Molecular Weight: 776.87
• Beilstein: 2228515
• EC Number: 200-101-1
• MDL number: MFCD00002595
• UNSPSC 코드: 12352209
• eCl@ss: 32190102
• PubChem Substance ID: 24899990
• NACRES: NA.77

속성

• 생물학적 소스: synthetic
• Quality Level: 200
• 제품 라인: BioReagent
• 분석: ≥98% (HPLC)
• 양식: powder
• 효능: 5-50 ng/mL
• 기술: cell culture | mammalian: suitable
• mp: 223 °C (dec.) (lit.)
• solubility: 4 M NH₄OH in methanol: 50 mg/mL, clear to hazy, yellow
• 배송 상태: ambient
• 저장 온도: room temp
• SMILES string: N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O
• InChI: 1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1
• InChI key: XUIIKFGFIJCVMT-LBPRGKRZSA-N
• 유전자 정보: human ... THRA(7067) , THRB(7068) , TTR(7276) ; mouse ... Cnr2(12802) ; rat ... Cnr1(25248)

설명

일반 설명

Thyroxine (T₄) is a tetraiodo derivative of the p-hydroxyphenyl ether of tyrosine,[1] which functions as growth factors or cell growth inhibitors.[2] T₄ is used to treat hypothyroidism[3] and thyroid carcinoma.[4] It regulates energy metabolism.[5]

애플리케이션

L-Thyroxine has been used to investigate its role in colorectal cancer cell lines HCT 116 (APC wild type) and HT-29 (APC mutant).[6] It has also been used to evaluate its effects on pro-inflammatory tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), angiogenic vascular endothelial growth factor (VEGF), leukocyte adhesion, intercellular adhesion molecule 1 (ICAM-1) and E-selectin in human umbilical vein endothelial cells (HUVECs).[7]

생화학적/생리학적 작용

L-Thyroxine (T₄) and triiodo-L-thyronine (T₃) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis.

제조 메모

For long term storage, keep stock solutions at -20° in working aliquots and avoid repeated freeze/thaw cycles. Solutions stored at 2-8 °C are stable for up to 30 days.

재구성

To prepare 20 μg/ml stock solution, dissolve in 50 ml sterile culture medium per mg thyroxine.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H372
• 예방조치 성명서: P260 - P264 - P270 - P314 - P501
• Hazard Classifications: STOT RE 1
• 표적 기관: Thyroid,Cardio-vascular system,Kidney
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)