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Merck
모든 사진(1)

주요 문서

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T1452

Sigma-Aldrich

TPCA-1

≥95% (HPLC)

동의어(들):

[5-(p-Fluorophenyl)-2-ureido]thiophene-3-carboxamide

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크기 선택

1 MG
₩313,737
5 MG
₩1,236,270

₩313,737

구입 가능 여부는 고객센터에 문의하십시오.
벌크 견적 요청
모든 사진(1)

크기 선택

보기 변경
1 MG
₩313,737
5 MG
₩1,236,270

About This Item

실험식(Hill 표기법):
C12H10FN3O2S
CAS Number:
507475-17-4
Molecular Weight:
279.29
MDL number:
MFCD09037541
UNSPSC 코드:
12352200
PubChem Substance ID:
329826675
NACRES:
NA.77

₩313,737

구입 가능 여부는 고객센터에 문의하십시오.
벌크 견적 요청

Quality Level

100

분석

≥95% (HPLC)

양식

powder

색상

white to light brown

solubility

DMSO: 5 mg/mL, clear

주관자

GlaxoSmithKline

저장 온도

2-8°C

SMILES string

NC(=O)Nc1sc(cc1C(N)=O)-c2ccc(F)cc2

InChI

1S/C12H10FN3O2S/c13-7-3-1-6(2-4-7)9-5-8(10(14)17)11(19-9)16-12(15)18/h1-5H,(H2,14,17)(H3,15,16,18)

InChI key

SAYGKHKXGCPTLX-UHFFFAOYSA-N

애플리케이션

TPCA-1 has been used to study its cytotoxic effects in RPMI8226 and LP1 cell lines[1]. It has also been used as a culture media supplement for nuclear protein fractions extracted from human airway smooth muscle cells[2].

생화학적/생리학적 작용

IKK-2 Inhibitor
TPCA-1 is a potent and selective inhibitor of human IκB kinase-2 (IKK-2) with IC50 = 17.9 nM for IKK-2 compared to 400nm for IKK-1. It has been used to study inhibition of IKK-2 to prevent inflammatory mediator release in animal models of arthritis and airway inflammation.

특징 및 장점

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

제조 메모

TPCA-1 is soluble in DMSO at a concentration that is greater than or equal to 10 mg/ml. It is insoluble in water.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves

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시험 성적서(COA)

Lot/Batch Number
0000158500
0000109522
0000108985
0000055317

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문서 라이브러리 방문

Y Gao et al.
Oncogenesis, 6(9), e383-e383 (2017-09-26)
Clinical and experimental evidence indicates that macrophages could promote solid-tumor progression and metastasis. However, the mechanisms underlying this process remain unclear. Here we show that yes-associated protein 1 (YAP1), a transcriptional regulator that controls tissue growth and regeneration, has an
Patricia L Podolin et al.
The Journal of pharmacology and experimental therapeutics, 312(1), 373-381 (2004-08-19)
Demonstration that IkappaB kinase 2 (IKK-2) plays a pivotal role in the nuclear factor-kappaB-regulated production of proinflammatory molecules by stimuli such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 suggests that inhibition of IKK-2 may be beneficial in the treatment
Lauren D Aarreberg et al.
mBio, 9(2) (2018-03-22)
Induction of interferon beta (IFN-β), IFN-stimulated genes (ISGs), and inflammatory responses is critical for control of viral infection. We recently identified an essential linkage of stimulation of the inflammatory cytokine interleukin-1β (IL-1β) and induction of ISGs that function as host
Ines Tagoug et al.
PloS one, 6(7), e22641-e22641 (2011-07-30)
Multiple myeloma (MM) is a B cell neoplasm characterized by bone marrow infiltration with malignant plasma cells. IGF-1 signalling has been explored as a therapeutic target in this disease. We analyzed the effect of the IKK2 inhibitor AS602868, in combination
Alice Borghi et al.
Biochemical pharmacology, 153, 292-298 (2018-01-30)
Tumor Necrosis Factor (TNF) is a proinflammatory cytokine that elicits its action by binding to two cell surface TNF receptors (TNFR), TNFR1 and TNFR2, which are expressed by many different cell types. Stimulation of TNFR1 activates canonical NF-κB signaling, leading
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