F6892

Farnesyl pyrophosphate ammonium salt

methanol:ammonia solution, ≥95% (TLC)

• 동의어(들): 3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl pyrophosphate ammonium salt, FPP
• 실험식(Hill 표기법): C₁₅H₃₇N₃O₇P₂
• CAS Number: 13058-04-3
• Molecular Weight: 433.42
• MDL number: MFCD00189688
• UNSPSC 코드: 12352204
• PubChem Substance ID: 24894923
• NACRES: NA.83

속성

• Quality Level: 100
• 분석: ≥95% (TLC)
• 형태: methanol:ammonia solution
• 포장: vial of 200 μg
• 저장 온도: −20°C
• SMILES string: C\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O
• InChI: 1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b14-9+,15-11+
• InChI key: VWFJDQUYCIWHTN-YFVJMOTDSA-N
• 유전자 정보: rat ... Fnta(25318)

설명

일반 설명

Farnesyl pyrophosphate is a 15-carbon isoprenoid synthesized from geranyl pyrophosphate (GPP) by the action of enzyme farnesyl pyrophosphate synthase (FPPS).

애플리케이션

Farnesyl pyrophosphate ammonium salt has been used:

• as a prenylation agonist in human osteogenic sarcoma cells in collagen-based cell invasion assays
• in the prenylation of the hepatocyte growth factor (HGF) in human umbilical vein endothelial cells (HUVECs)
• as a substrate in prenyltransferases assay in diatom Haslea ostrearia

생화학적/생리학적 작용

Farnesyl pyrophosphate (FPP) is the precursor for the biosynthesis of cholesterol, ubiquinone and dolicol. It is part of the intracellular mevalonate pathway. FPP is essential for cell survival and is used for prenylation of several low molecular mass G proteins, including Ras. Inhibition of prenylation results in loss of oncogenic potential of Ras proteins. Inhibition of prenylation may serve as therapeutic potential for management of synaptic plasticity and Alzheimer′s disease.

물리적 형태

Solution in methanol: 10mM aqueous NH₄OH (7:3)
Actual concentration given on label

안전성 정보

• 픽토그램: GHS02,GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H225,H301 + H311 + H331,H315,H319,H370,H412
• 예방조치 성명서: P210 - P273 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 1
• 표적 기관: Eyes,Central nervous system
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point (°F): 60.8 °F
• Flash Point (°C): 16 °C