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Merck
모든 사진(3)

주요 문서

T0281

Sigma-Aldrich

3,3′,5′-Triiodo-L-thyronine

thyroid hormone analog

동의어(들):

Reverse T3, rT(3)

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About This Item

실험식(Hill 표기법):
C15H12I3NO4
CAS Number:
Molecular Weight:
650.97
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.26

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분석

≥97.0% (HPLC)

양식

powder

기술

cell culture | mammalian: suitable

저장 온도

−20°C

SMILES string

N[C@@H](Cc1ccc(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1

InChI key

HZCBWYNLGPIQRK-LBPRGKRZSA-N

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애플리케이션

3,3′,5′-Triiodo-L-thyronine has been used as a supplement in cell culture media for generation of oligodendrocyte lineage cells from human pluripotent stem cells.[1] It has also been used as a supplement to culture epithelial tissue in vitro.[2]

생화학적/생리학적 작용

3,3′,5′-Triiodo-L-thyronine (T3) is an endocrine hormone produced by the thyroid gland and is regarded as an active thyroid hormone at cellular level.[3][4] The interaction of T3 with nonhistone proteins in the chromatin initiates the thyroid hormone activity. Thyroid hormones regulate the differentiation and development of tissue and affect a number of metabolic processes.[5] The level of circulating T3 hormone is reduced in hypothyroidism.[3]
rT3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes.[6] The ratio of triiodothryonine (T3) to rT3 has been investigated as in indicator of insulin resistance.[7]

픽토그램

Exclamation mark

신호어

Warning

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves


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문서 라이브러리 방문

Reporting on methods to generate and purify rodent and human oligodendrocytes from different sources
MehdiDjelloul
Stem Cell Research, 20, 58-66 (2017)
Victor R. Preedy
Handbook of Behavior, Food and Nutrition, 2109-2109 (2011)
Tatsuya Kunisue et al.
Analytical chemistry, 83(1), 417-424 (2010-12-03)
Thyroid hormones (THs) play critical roles in the regulation of growth and development, including brain development, in both humans and animals. Until recently, TH levels were assayed with measurements in serum, using immunoassay (IA)-based methods. IA methods are sensitive but
Enrique Pimentel
Hormones Growth Factors & Oncogenes, 219-219 (1987)
An Jacobs et al.
Thyroid : official journal of the American Thyroid Association, 29(4), 480-492 (2019-02-15)
Non-thyroidal illness (NTI), which occurs with fasting and in response to illness, is characterized by thyroid hormone inactivation with low triiodothyronine (T3) and high reverse T3 (rT3), followed by suppressed thyrotropin (TSH). Withholding supplemental parenteral nutrition early in pediatric critical

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