SRP8039
Irisin
recombinant, expressed in CHO cells, FLAG® tagged, >95% (SDS-PAGE)
동의어(들):
CD121a, Fibronectin type III domain-containing protein 5 (cleaved), Fibronectin type III repeat-containing protein 2 (cleaved)
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크기 선택
10 μG
₩1,072,348
₩1,072,348
출고 가능일2025년 4월 14일세부사항
모든 사진(1)
크기 선택
보기 변경
10 μG
₩1,072,348
About This Item
₩1,072,348
출고 가능일2025년 4월 14일세부사항
추천 제품
재조합
expressed in CHO cells
태그
FLAG® tagged
분석
>95% (SDS-PAGE)
양식
lyophilized
분자량
~26 kDa
포장
pkg of 10 μg
불순물
<0.1 EU/μg endotoxin, tested
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
human ... FNDC5(252995)
일반 설명
Irisin is an described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin is cleaved from the type I membrane protein FNDC5 (fibronectin type III domain containing 5).[1][2] FNDC5 is mainly expressed in the muscles. Low levels of the mRNA are also present in the kidney, liver and lung.[2] The gene encoding irisin is mapped to human chromosome 1p35.1.[3]
생화학적/생리학적 작용
Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin) and improves systemic metabolism by increasing energy expenditure.[1][2] It is mainly responsible for the conversion of white fat into brown fat. This conversion enhances metabolic uncoupling and caloric expenditure.[1] Irisin is always associated with beneficial responses of exercise on cellular metabolism.[2] In obese and type 2 diabetic patients, low levels of circulating irisin are characteristic of the adipose tissue and muscle.[4]
물리적 형태
Lyophilized from PBS.
재구성
Reconstitute with 100 μL deionized water.
기타 정보
Irisin (human, aa 16-127 /mouse, aa 29-140) is Flag-tagged at the N-terminus. Irisin has 100% identity betwen mouse, rat, monkey and human.
법적 정보
FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity.
Staiger H, et al.
PLoS ONE, 8, e61903-e61903 (2013)
FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise.
Huh JY, et al.
Metabolism, Clinical and Experimental, 61, 1725-1725 (2012)
Is irisin a human exercise gene?
Timmons JA
Nature, 488, E9-10 (2012)
Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance.
Moreno-Navarrete JM, et al.
The Journal of Clinical Endocrinology and Metabolism, 98, E769-E778 (2013)
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.
