추천 제품
생물학적 소스
human
재조합
expressed in E. coli
분석
≥95% (HPLC)
≥95% (SDS-PAGE)
양식
lyophilized
효능
501.0-2.0 μg/mL ED50
분자량
~11.2 kDa
포장
pkg of 20 μg
불순물
endotoxin, tested
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
human ... CTGF(1490)
일반 설명
The gene CTGF (connective tissue growth factor) is mapped to human chromosome 6q23.2.[1] CTGF is a member of the CCN (Cyr61, CTGF , Nov) family of secreted cysteine rich regulatory proteins and is the major mitogenic and chemoattractant protein produced by umbilical vein and vascular endothelial cells.[2][3][4] The protein has an N-terminal secretory signal peptide and four domains (an insulin-like growth factor-binding protein domain, a Von Willebrand factor domain, a thrombospondin type-1 repeat module, and a CT).[2] It is expressed in various tissues, such as connective tissue, heart, brain, kidney, lung, liver, muscle, pancreas gland and placenta.[4] Recombinant human CTGF is a 11.2Da protein of 98 amino acid residues.
생화학적/생리학적 작용
CTGF (connective tissue growth factor) stimulates the proliferation and differentiation of chondrocytes, induces angiogenesis, promotes cell adhesion of fibroblasts, endothelial, and epithelial cells.[5][6][7] It binds to IGF (insulin growth factor), TGF (transforming growth factor) β1 and BMP (bone morphogenetic protein)-4. CTGF plays a crucial role in the progression of diabetic nephropathy.[3] It can work as an oncoprotein in glioma and melanoma. However, it works as a tumor suppressor in lung cancer and colon cancer.[8]
물리적 형태
Sterile filtered and Lyophilized without additives.
재구성
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
Hsiao-Chi Tsai et al.
Oncotarget, 5(11), 3800-3812 (2014-07-09)
Osteosarcoma, the most common primary malignant bone tumor, shows potent capacity for local invasion and distant metastasis. Connective tissue growth factor (CTGF/CCN2), a secreted protein, binds to integrins, modulates invasive behavior of certain human cancer cells. Effect of CTGF in
S-C Liu et al.
Cell death & disease, 5, e1485-e1485 (2014-10-24)
Connective tissue growth factor (CTGF, a.k.a. CCN2) is inflammatory mediator and abundantly expressed in osteoarthritis (OA). Angiogenesis is essential for OA progression. Here, we investigated the role of CTGF in vascular endothelial growth factor (VEGF) production and angiogenesis in OA
The Twisted gastrulation family of proteins, together with the IGFBP and CCN families, comprise the TIC superfamily of cysteine rich secreted factors.
Vilmos P, et al.
Molecular Pathology, 54, 317-323 (2001)
Sandi G Dempsey et al.
Journal of proteome research, 18(4), 1657-1668 (2019-03-19)
Ovine forestomach matrix (OFM) is a decellularized extracellular matrix (dECM) biomaterial that serves as a scaffold for remodeling damaged soft tissue. dECM biomaterials are used in a variety of clinical applications, and their regenerative capacity is encoded not only in
The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion.
Ball DK, et al.
The Journal of Endocrinology, 176, R1-R7 (2003)
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