SML3998

NVP-AUY922

≥98% (HPLC)

• 동의어(들): 5-(2,4-Dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide, 5-[2,4-Dihydroxy-5-(1-methylethyl)phenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide, AUY922, Luminespib, VER 52296, VER-52296, VER52296
• 실험식(Hill 표기법): C₂₆H₃₁N₃O₅
• CAS Number: 747412-49-3
• Molecular Weight: 465.54
• MDL number: MFCD14635361
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: O=C(C1=NOC(C2=C(O)C=C(O)C(C(C)C)=C2)=C1C3=CC=C(CN4CCOCC4)C=C3)NCC
• InChI: 1S/C26H31N3O5/c1-4-27-26(32)24-23(18-7-5-17(6-8-18)15-29-9-11-33-12-10-29)25(34-28-24)20-13-19(16(2)3)21(30)14-22(20)31/h5-8,13-14,16,30-31H,4,9-12,15H2,1-3H3,(H,27,32)
• InChI key: NDAZATDQFDPQBD-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

High-affinity, potent and selective heat shock protein 90 (HSP90α/β) inhibitor with anti-cancer efficacy in cultures and in vivo.



NVP-AUY922 (Luminespib; VER-52296) is a high-affinity (HSP90β Kd = 1.7 nM), potent and selective heat shock protein 90 inhibitor (HSP90α/β Ki = 9.0/8.2 nM, HSP90α/β IC50 = 7.8/21 nM) that exhibits anti-proliferation potency in cancer cultures (GI50 from 2 to 40 nM among 29 cancer lines) and anti-tumor efficacy in vivo (50-75 mg/kg/day i.p.) by inducing cancer cells G1-G2 arrest and apoptosis.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable