SML3340

Sgl1 inhibitor Hit 1

≥98% (HPLC)

• 동의어(들): 4-Hydroxy-1-[[2-(3-methoxyphenyl)-5-thiazolyl]methyl]-4-piperidinemethanol
• 실험식(Hill 표기법): C₁₇H₂₂N₂O₃S
• CAS Number: 1332191-15-7
• Molecular Weight: 334.43
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: COC1=CC=CC(C2=NC=C(S2)CN3CCC(O)(CC3)CO)=C1
• InChI key: FXCZNKJONOHACS-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

Cell penetrant, potent and low toxic inhibitor of Cryptococcus neoformans sterylglucosidase 1 (Sgl1)

Sgl1 inhibitor Hit 1 is a cell penetrant, potent and low toxic inhibitor of Cryptococcus neoformans sterylglucosidase 1 (Sgl1) that significantly increases in the intracellular concentration of ergosterol 3β-D-glucoside (erg-glc). Sgl1 inhibitor Hit 1 potently inhibits growth of wild-type C. neoformans. Also, it inhibits brain dissemination of C. neoformans in a mouse model of infection.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable