SML1892
JPH203 hydrochloride
≥98% (HPLC)
동의어(들):
(S)-2-Amino-3-(4-((5-amino-2-phenylbenzo[d]oxazol-7-yl)methoxy)-3,5-dichlorophenyl)propanoic acid hydrochloride, JPH 203 hydrochloride, KYT 0353 hydrochloride, KYT-0353 hydrochloride, KYT0353 hydrochloride, O-(5-Amino-2-phenylbenzoxazole-7-yl)methyl-3,5-dichloro-L-tyrosine hydrochloride, O-[(5-Amino-2-phenyl-7-benzoxazolyl)methyl]-3,5-dichloro-L-tyrosine dihydrochloride, SCHEMBL17360639 hydrochloride
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C23H19Cl2N3O4 · xHCl
CAS Number:
Molecular Weight:
472.32 (free base basis)
MDL number:
UNSPSC 코드:
12352200
추천 제품
분석
≥98% (HPLC)
양식
powder
저장 조건
desiccated
색상
white to beige
solubility
DMSO: 15 mg/mL, clear
저장 온도
2-8°C
SMILES string
O=C(O)[C@@H](N)CC1=CC(Cl)=C(OCC2=CC(N)=CC3=C2OC(C4=CC=CC=C4)=N3)C(Cl)=C1
생화학적/생리학적 작용
A selective LAT1 inhibitor that blocks LAT1-dependent L-Leu uptake and cancer growth both in vitro and in vivo.
JPH203 (KYT-0353) selectively inhibits L-type amino acid transporter LAT1-dependent L-leucine uptake and growth in HT-29 and human LAT1-expressing S2 murine renal proximal tubule cell cultures, but not human LAT2-expressing S2 cells (IC50/GI50 = 0.06/4.1, 0.14/16.4, and >10/>1000 μM, respectively). When administered via intravenous injection (6.3-25 mg/kg/d from d0 to d13), JPH203 effectively inhibits HT-29-derived tumor growth in mice in vivo.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
Gyujin Park et al.
JCI insight, 8(7) (2023-03-03)
Hypothalamic neurons regulate body homeostasis by sensing and integrating changes in the levels of key hormones and primary nutrients (amino acids, glucose, and lipids). However, the molecular mechanisms that enable hypothalamic neurons to detect primary nutrients remain elusive. Here, we
Michael F Wempe et al.
Drug metabolism and pharmacokinetics, 27(1), 155-161 (2011-09-15)
Many primary human tumors and tumor cell lines highly express human L-type amino acid transporter 1 (hLAT1); cancerous cells in vivo are strongly linked to LAT1 expression. Synthetic chemistry and in vitro screening efforts have afforded a variety of novel
Koji Oda et al.
Cancer science, 101(1), 173-179 (2009-11-11)
Most tumor cell membranes overexpress L-type amino acid transporter 1, while normal cell membranes contain l-type amino acid transporter 2; both are Na(+)-independent amino acid transporters. Therefore, compounds that selectively inhibit L-type amino acid transporter 1 offer researchers with a
Yi-Heng Liu et al.
International journal of molecular sciences, 22(20) (2021-10-24)
The l-type amino acid transporter 1 (LAT1) is a membranous transporter that transports neutral amino acids for cells and is dysregulated in various types of cancer. Here, we first observed increased LAT1 expression in pemetrexed-resistant non-small cell lung cancer (NSCLC)
Junko Toyoshima et al.
Journal of pharmaceutical sciences, 102(9), 3228-3238 (2013-05-29)
JPH203 has been developed as an anticancer drug that inhibits L-type amino acid transporter 1-mediated essential amino acid uptake into tumor cells. This study sought to elucidate which drug transporters may be involved in JPH203 hepatic elimination, and to estimate
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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