SML2670
BAY-8002
≥98% (HPLC)
동의어(들):
2-(2-chloro-5-(phenylsulfonyl)benzamido)benzoic acid, 2-[[2-Chloro-5-(phenylsulfonyl)benzoyl]amino]-benzoic acid
로그인조직 및 계약 가격 보기
크기 선택
5 MG
₩133,371
25 MG
₩537,240
모든 사진(1)
크기 선택
보기 변경
5 MG
₩133,371
25 MG
₩537,240
About This Item
실험식(Hill 표기법):
C20H14ClNO5S
CAS Number:
Molecular Weight:
415.85
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
분석
≥98% (HPLC)
양식
powder
색상
white to beige
solubility
DMSO: 2 mg/mL, clear
저장 온도
2-8°C
SMILES string
[S](=O)(=O)(c2cc(c(cc2)Cl)C(=O)Nc3c(cccc3)C(=O)O)c1ccccc1
InChI
1S/C20H14ClNO5S/c21-17-11-10-14(28(26,27)13-6-2-1-3-7-13)12-16(17)19(23)22-18-9-5-4-8-15(18)20(24)25/h1-12H,(H,22,23)(H,24,25)
InChI key
CLAUJSRBKSRTGQ-UHFFFAOYSA-N
생화학적/생리학적 작용
BAY-8002 is an orally available, potent and selective inhibitor of lactate transporter MCT1 (monocarboxylate transporter 1; SLC16A1) that potently inhibits bidirectional lactate transport. BAY-8002 exhibits antiproliferative activity in numerous cancer cell lines. BAY-8002 induces accumulation of lactate and significantly inhibits tumor growth in mice model. It does not cause tumor regression.
orally available, potent and selective inhibitor of lactate transporter MCT1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
Maria Quanz et al.
Molecular cancer therapeutics, 17(11), 2285-2296 (2018-08-18)
The lactate transporter SLC16A1/monocarboxylate transporter 1 (MCT1) plays a central role in tumor cell energy homeostasis. In a cell-based screen, we identified a novel class of MCT1 inhibitors, including BAY-8002, which potently suppress bidirectional lactate transport. We investigated the antiproliferative
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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