SML1687
3BDO
≥98% (HPLC)
동의어(들):
3-Benzyl-5-((2-nitrophenoxy)methyl)-dihydrofuran-2(3H)-one
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크기 선택
5 MG
₩161,182
25 MG
₩651,732
모든 사진(1)
크기 선택
보기 변경
5 MG
₩161,182
25 MG
₩651,732
About This Item
실험식(Hill 표기법):
C18H17NO5
CAS Number:
Molecular Weight:
327.33
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.32
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
oil
색상
colorless to light brown
저장 온도
2-8°C
SMILES string
O=C1OC(COC2=C([N+]([O-])=O)C=CC=C2)CC1CC3=CC=CC=C3
InChI
1S/C18H17NO5/c20-18-14(10-13-6-2-1-3-7-13)11-15(24-18)12-23-17-9-5-4-8-16(17)19(21)22/h1-9,14-15H,10-12H2
InChI key
AXPZIVKEZRHGAS-UHFFFAOYSA-N
애플리케이션
3BDO has been used to investigate the potential effects of metformin on inflammatory lung injury.[1]
생화학적/생리학적 작용
3BDO is a cell-permeable, orally bioavailable, non-toxic butyrolactone derivative that is shown to competitively bind FKBP1A (FK506-binding protein 1A, 12 kDa) in a reversible manner, and suppress autophagy via the mTOR pathway. 3BDO inhibits both LPS- and oxLDL-induced autophagy in HUVECs, increases TIA1 phosphorylation, and reduces autophagosomes number. It is reported to be brain permeant, and significantly decreases atherosclerosis development in apoE-/- mice (100 mg/kg, q.d., p.o.). 3BDO increases IDE and neprilysin levels, lowers amyloid-β deposition in an AβPP/PS1 transgenic mouse model of Alzheimer′s disease, and alleviates memory deficits.
An orally bioavailable, brain-permeant suppressor of mTOR-mediated autophagy; reduces Aβ levels and prevents cognitive deficits in AβPP/PS1 mouse model.
An orally bioavailable, brain-permeant suppressor of mTOR-mediated autophagy; reduces Aβ levels and prevents cognitive deficits in AβPP/PS1 mouse model.
3-benzyl-5-[(2-nitrophenoxy) methyl]-dihydrofuran-2 (3H)-one (3BDO) blocks rise in LC3-II stimulated by uric acid (UA).[2] It protects the capability of Rheb1-deficient macrophages to perform phagocytosis.[3] 3BDO also prevents the inhibitory effects of EX-527 on eukaryotic translation initiation factor-binding protein 1(4E-BP1) phosphorylation.[4]
3-benzyl-5-[(2-nitrophenoxy) methyl]-dihydrofuran-2 (3H)-one (3BDO) blocks rise in LC3-II stimulated by uric acid (UA).[2] It protects the capability of Rheb1-deficient macrophages to perform phagocytosis.[3] 3BDO also prevents the inhibitory effects of EX-527 on eukaryotic translation initiation factor-binding protein 1(4E-BP1) phosphorylation.[4]
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
Rheb1-mTORC1 maintains macrophage differentiation and phagocytosis in mice.
Wang X, et al.
Experimental Cell Research, 344(2), 219-228 (2016)
Metformin alleviated endotoxemia-induced acute lung injury via restoring AMPK-dependent suppression of mTOR.
Wu K, et al.
Chemico-Biological Interactions, 291, 1-6 (2018)
Yu-Lan Sheng et al.
Experimental neurology, 297, 138-147 (2017-08-20)
Serum urate levels are reported to be significantly lowered in patients with Parkinson's disease (PD) and inversely correlated to the risk and progression of PD. However, the mechanism by which urate affects PD is poorly understood. Here we showed that
The SIRT1 inhibitor EX-527 suppresses mTOR activation and alleviates acute lung injury in mice with endotoxiemia.
Huang J, et al.
Innate Immunity, 23(8), 678-686 (2017)
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.
