SML1629

Ezetimibe

≥98% (HPLC)

• 동의어(들): (3R,4S)-1-(4-Fluorophenyl)-3-[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one
• 실험식(Hill 표기법): C₂₄H₂₁F₂NO₃
• CAS Number: 163222-33-1
• Molecular Weight: 409.43
• MDL number: MFCD00937872
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825513
• NACRES: NA.77

속성

• Quality Level: 200
• 분석: ≥98% (HPLC)
• 양식: powder
• solubility: DMF: soluble ≥15 mg/mL; DMSO: soluble ≥15 mg/mL; ethanol: soluble ≥15 mg/mL; methanol: soluble ≥15 mg/mL
• 저장 온도: 2-8°C
• SMILES string: FC(C=C1)=CC=C1N([C@H](C2=CC=C(O)C=C2)[C@H]3CC[C@H](O)C4=CC=C(F)C=C4)C3=O
• InChI: 1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1
• InChI key: OLNTVTPDXPETLC-XPWALMASSA-N

설명

생화학적/생리학적 작용

Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by Niemann-Pick C1 Like 1 (NPC1L1) protein that was found critical for the intestinal absorption of cholesterol. Ezetimibe selectvely blocks cholesterol absorption without inhibiting pancreatic lipolytic enzyme activities in the intestinal lumen.

Ezetimibe is a non statin drug that reduces intestinal cholesterol absorption. In addition, it also has an ability to reduce the risk of cardiovascular events in patients who had had an acute coronary syndrome and whose low-density lipoprotein (LDL) cholesterol values were within guideline recommendations.[1]

재구성

For solubility in aqueous buffer, Ezetimibe should be dissolved in ethanol followed by dilution with the buffer.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable