D6821

Donepezil hydrochloride

≥98% (HPLC), powder, acetylcholinesterase inhibitor

• 동의어(들): 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride, E2020
• 실험식(Hill 표기법): C₂₄H₂₉NO₃ · HCl
• CAS Number: 120011-70-3
• Molecular Weight: 415.95
• MDL number: MFCD00881312
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329798838
• NACRES: NA.77

속성

• product name: Donepezil hydrochloride, ≥98% (HPLC)
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: powder
• 저장 조건: desiccated
• 색상: white to off-white
• solubility: DMSO: ≥20 mg/mL; H₂O: ≥20 mg/mL
• 저장 온도: room temp
• SMILES string: O=C1C(CC2CCN(CC3=CC=CC=C3)CC2)CC4=CC(OC)=C(OC)C=C41.[H]Cl
• InChI: 1S/C24H29NO3.ClH.H2O/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H;1H2
• InChI key: HLJIZAKUNCTCQX-UHFFFAOYSA-N
• 유전자 정보: human ... ACHE(43)

설명

애플리케이션

Donepezil hydrochloride has been used in dose-response experiment to study its efficacy in ameliorating nicotine withdrawal-induced deficits in contextual conditioning in mice. It has also been intraperitoneally injected into rats to study its ability to improve social behavioral deficits, repetitive behavior and hyperactivity.

생화학적/생리학적 작용

Donepezil hydrochloride is a piperidine containing an organic compound and a non-competitive inhibitor. It is useful in treating Alzheimer′s disease, in which dementia is a prominent symptom. Donepezil is shown to induce cognitive ability and overall body function. It has a half-life of 70 hours.

Donepezil monohydrochloride monohydrate is a centrally acting reversible acetylcholinesterase inhibitor.

특징 및 장점

This compound is featured on the Acetylcholine Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H300,H319
• 예방조치 성명서: P264 - P270 - P280 - P301 + P310 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Acute Tox. 2 Oral - Eye Irrit. 2
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable