SML1237

CCT137690

≥98% (HPLC)

• 동의어(들): 6-Bromo-7-[4-[(5-methyl-3-isoxazolyl)methyl]-1-piperazinyl]-2-[4-(4-methyl-1-piperazinyl)phenyl]-3H-imidazo[4,5-b]pyridine
• 실험식(Hill 표기법): C₂₆H₃₁BrN₈O
• CAS Number: 1095382-05-0
• Molecular Weight: 551.48
• MDL number: MFCD18206879
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825737
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear (warmed)
• 저장 온도: −20°C
• SMILES string: CN(CC1)CCN1C(C=C2)=CC=C2C3=NC4=C(N5CCN(CC6=NOC(C)=C6)CC5)C(Br)=CN=C4N3
• InChI: 1S/C26H31BrN8O/c1-18-15-20(31-36-18)17-33-9-13-35(14-10-33)24-22(27)16-28-26-23(24)29-25(30-26)19-3-5-21(6-4-19)34-11-7-32(2)8-12-34/h3-6,15-16H,7-14,17H2,1-2H3,(H,28,29,30)
• InChI key: GFLQCBTXTRCREJ-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

CCT137690 is a very potent, orally bioavailble, pan aurora kinase inhbitor (IC₅₀ = 15, 25, and 19 nM for Aurora A, B and C respectively). CCT137690 inhibits tumor growth in amouse xenograft model and causes multipolar spindle formation, chromosome misalignment, polyploidy and apoptosis in tumor cell lines.

CCT137690 is a very potent, orally bioavailble, pan aurora kinase inhbitor.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable