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Merck
모든 사진(1)

주요 문서

329600

Sigma-Aldrich

Erastin

≥98% (HPLC), solid, antitumor agent, Calbiochem®

동의어(들):

Erastin, 2-(1-(4-(2-(4-Chlorophenoxy)acetyl)-piperazin-1-yl)-ethyl)-3-(2-ethoxyphenyl)-3H-quinazolin-4-one

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C30H31ClN4O4
CAS Number:
571203-78-6
Molecular Weight:
547.04
MDL number:
MFCD09837984
UNSPSC 코드:
12352200
NACRES:
NA.77

제품명

Erastin, A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality.

Quality Level

100

분석

≥98% (HPLC)

양식

solid

제조업체/상표

Calbiochem®

저장 조건

OK to freeze
protect from light

색상

white

solubility

DMSO: 50 mg/mL

배송 상태

wet ice

저장 온도

−20°C

SMILES string

Clc1ccc(cc1)OCC(=O)N2CCN(CC2)C(C)c3[n]([c](c5c(n3)cccc5)=O)c4c(cccc4)OCC

InChI

1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3

InChI key

BKQFRNYHFIQEKN-UHFFFAOYSA-N

일반 설명

A cell-permeable piperazinyl-quinazolinone compound that exhibits oncogene-selective lethality. Shown to bind mitochondrial voltage-dependent anion channels (VDAC) and alter its gating; rapidly induce an oxidative, non-apoptotic cell death in several human tumors harboring activating mutations in the RAS-RAF-MEK signaling (EC50 = 6.0 µM in BJ-TERT/LT/ST/RASV12 cells).

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

기타 정보

Yagoda, N., et al. 2007. Nature447, 864.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

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