SML1083
Ethacrynic acid
≥97% (HPLC)
동의어(들):
2-[2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy]acetic acid, ECA, Etacrynic acid, [2,3-Dichloro-4-(2-ethylacryloyl)phenoxy]acetic acid, (2,3-Dichloro-4-[2-methylenebutyryl]phenoxy)acetic acid
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모든 사진(1)
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10 MG
₩76,937
About This Item
실험식(Hill 표기법):
C13H12Cl2O4
CAS Number:
Molecular Weight:
303.14
EC Number:
MDL number:
UNSPSC 코드:
12352106
PubChem Substance ID:
NACRES:
NA.77
추천 제품
분석
≥97% (HPLC)
양식
powder
색상
white to beige
solubility
DMSO: 20 mg/mL, clear
저장 온도
2-8°C
SMILES string
ClC1=C(Cl)C(C(C(CC)=C)=O)=CC=C1OCC(O)=O
InChI
1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17)
InChI key
AVOLMBLBETYQHX-UHFFFAOYSA-N
유전자 정보
human ... SLC12A1(6557)
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생화학적/생리학적 작용
Ethacrynic acid increases the cytotoxicity of chlorambucil in rat and human tumor cell lines.[1]
Ethacrynic acid is non sulfonamide loop diuretic that is used to treat high blood pressure and the swelling caused by diseases like congestive heart failure. Ethacrynic acid blocks sodium-potassium-chloride cotransport. Also, Ethacrynic acid potently inhibits glutathione S-transferase family members. Studies show that ethacrynic acid potently inhibits Tgase-2 (transglutaminase-2) dependent metastasis of cancer cells including lung and pancreatic cancers.
신호어
Warning
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
E Röth et al.
Experimental and clinical cardiology, 16(3), 92-96 (2011-11-09)
Oxidative stress and ischemia-reperfusion (I/R) injury are crucial in the pathogenesis of cardiovascular diseases. The antioxidant glutathione S-transferase (GST) is responsible for the high-capacity metabolic inactivation of electrophilic compounds and toxic substrates. The main objective of the present study was
Maria Font Farre et al.
Plant & cell physiology, 65(1), 128-141 (2023-11-04)
Glutathione transferases (GSTs) represent a large and diverse enzyme family involved in the detoxification of small molecules by glutathione conjugation in crops, weeds and model plants. In this study, we introduce an easy and quick assay for photoaffinity labeling of
Inhibition of rat and human glutathione S-transferase isoenzymes by ethacrynic acid and its glutathione conjugate.
Ploemen J H, et al.
Biochemical Pharmacology, 40(7), 1631-1635 (1990)
Piriyaporn Thiendedsakul et al.
Veterinary world, 15(1), 46-54 (2022-04-05)
The crocodile is a model for studying relevant sources of environmental contamination. They were determined an appropriate biomonitoring species for various toxins. The cytosolic and microsomal fraction of crocodiles plays a role in detoxifying xenobiotics. Cytochrome P450 1A2 (CYP1A2) metabolizes
Ruina Wang et al.
Nature communications, 14(1), 5984-5984 (2023-09-27)
Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme environmental conditions. However, pharmacological induction of hypothermia in most mammals remains a huge challenge. Here we show that a natural product P57 promptly induces hypothermia and decreases energy
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