M9292

Memantine hydrochloride

≥98% (GC), powder, NMDA glutamate receptor antagonist

• 동의어(들): 3,5-Dimethyl-1-adamantanamine hydrochloride, 3,5-Dimethylamantadine hydrochloride, 3,5-Dimethyltricyclo[3.3.1.1^3,7]decan-1-amine hydrochloride
• 실험식(Hill 표기법): C₁₂H₂₁N · HCl
• CAS Number: 41100-52-1
• Molecular Weight: 215.76
• EC Number: 255-219-6
• MDL number: MFCD00214336
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24277990
• NACRES: NA.77

속성

• 제품명: Memantine hydrochloride, ≥98% (GC)
• 분석: ≥98% (GC)
• 양식: powder
• 주관자: Forest Labs
• SMILES string: Cl.C[C@]12CC3C[C@](C)(C1)CC(N)(C3)C2
• InChI: 1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H/t9-,10+,11-,12-;
• InChI key: LDDHMLJTFXJGPI-VXMZOEJHSA-N
• 유전자 정보: human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)

설명

애플리케이션

Memantine hydrochloride has been used:

• as a media supplement to serve as a control to study the neuroprotective effects of erythropoietin in N-methyl-D-aspartate receptor-induced toxicity[1]
• to intraperitoneally inject experimental animal to study its effect on traumatic injury[2]
• as a test compound to determine the dynamic range and selectivity of retinal pigment epithelium tissue penetration[3]

생화학적/생리학적 작용

Low-affinity NMDA glutamate receptor antagonist; stimulates dopamine release.

Memantine is effective against Alzheimer′s disease and Parkinson′s disease. It is also useful in treating epilepsy, motor neurone disease and trauma.[4]

특징 및 장점

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Forest Labs. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)