SML0723

ML252

≥98% (HPLC)

• 동의어(들): (S)-2-Phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide
• 실험식(Hill 표기법): C₂₀H₂₄N₂O
• CAS Number: 1392494-64-2
• Molecular Weight: 308.42
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: , light to dark purple
• solubility: DMSO: 25 mg/mL, clear
• 저장 온도: 2-8°C

설명

생화학적/생리학적 작용

ML252 is a potent, brain penetrant potassium channel Kv7.2 (KCNQ2) inhibitor with an IC₅₀ of 69 nM. ML252 is only slightly selective over KCNQ3 and KCNQ4 but is over 40-fold selective for KCNQ2 vs KCNQ1, unlike other KCNQ inbhibitors currently used. ML252 was also selective vs. >68 tested GPCRs, ion channels, and transporters. Potassium channel Kv7.2 has become a new target for Alzheimer′s Disease drug research because inhibiting it enhances acetylcholine release. SAR studies showed a small structural change from ethyl group to hydrogen resulted in a functional shift from antagonist to agonist activity (37, EC₅₀ of 170 nM), suggesting an interaction at a critical site for controlling KCNQ2 channel gating.

ML252 is a potent, brain penetrant potassium channel Kv7.2 (KCNQ2) inhibitor.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable