추천 제품
양식
solid
색상
yellow
solubility
DMSO: 10 mg/mL, clear
저장 온도
−20°C
SMILES string
COc1cccc(c1N)C2=CC(=O)c3ccccc3O2
InChI
1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
InChI key
QFWCYNPOPKQOKV-UHFFFAOYSA-N
유전자 정보
human ... MAP2K1(5604) , MAP2K2(5605) , MAP2K3(5606) , MAP2K4(6416) , MAP2K5(5607) , MAP2K6(5608) , MAP2K7(5609) , MAP3K1(4214) , RAF1(5894)
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애플리케이션
PD 98,059 has been used:
- in growth medium as a mitogen-activated protein (MAP) kinase inhibitor, in order to study the secondary messengers involved in the effect of D1-like receptors[1]
- in calcium-free RPMI (Roswell park memorial institute)-1640 medium to study its effect on inflammation, proliferation and differentiation in human epidermal keratinocyte cell line in conjunction of cystic fibrosis transmembrane conductance regulator (CFTR) knockdown[2]
- in culture medium for cell migration assay[3]
생화학적/생리학적 작용
PD 98,059 is a flavonoid[4] and specific inhibitor of mitogen-activated protein kinase kinase (MAPKK). In mice, PD 98,059 helps to block zymosan stimulated organ dysfunction syndrome and non-septic shock.[5] It is known to inhibit in vitro hypertrophy. PD 98,059 also induces cartilage formation in mesenchymal stromal cells.[6]
특징 및 장점
This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
법적 정보
Sold with permission of Warner Lambert Company.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
개인 보호 장비
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
이미 열람한 고객
Sepsis: Advances in Research and Treatment: 2011 Edition, 38-38 (2012)
Epidermal CFTR suppresses MAPK/NF-kappaB to promote cutaneous wound healing
Chen J
Cellular Physiology and Biochemistry, 39(6), 2262-2274 (2016)
Vasopressin V1A receptor mediates cell proliferation through GRK2-EGFR-ERK1/2 pathway in A7r5 cells.
Lingling Zhang et al.
European journal of pharmacology, 792, 15-25 (2016-11-05)
Abnormal proliferation and hypertrophy of vascular smooth muscle (VSMC), as the main structural component of the vasculature, is an important pathological mechanism of hypertension. Recently, increased levels of arginine vasopressin (AVP) and copeptin, the C-terminal fragment of provasopressin, have been
D1-like receptors inhibit insulin-induced vascular smooth muscle cell proliferation via down-regulation of insulin receptor expression
Zeng C, et al.
Journal of Hypertension, 27(5), 1033-1033 (2009)
Ki-Sun Park et al.
Nucleic acids research, 45(22), 12766-12779 (2017-12-16)
Imprinted genes occur in discrete clusters that are coordinately regulated by shared DNA elements called Imprinting Control Regions. H19 and Igf2 are linked imprinted genes that play critical roles in development. Loss of imprinting (LOI) at the IGF2/H19 locus on
활성 필터
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