SML2780
ML402
≥98% (HPLC)
동의어(들):
N-[2-(4-Chloro-2-methylphenoxy)ethyl]-2-thiophenecarboxamide, N-[2-(4-Chloro-2-methylphenoxy)ethyl]thiophene-2-carboxamide
로그인조직 및 계약 가격 보기
크기 선택
5 MG
₩143,826
25 MG
₩476,949
모든 사진(1)
크기 선택
보기 변경
5 MG
₩143,826
25 MG
₩476,949
About This Item
실험식(Hill 표기법):
C14H14ClNO2S
CAS Number:
Molecular Weight:
295.78
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
white to beige
solubility
DMSO: 2 mg/mL, clear
저장 온도
−20°C
SMILES string
ClC1=CC=C(OCCNC(C2=CC=CS2)=O)C(C)=C1
InChI
1S/C14H14ClNO2S/c1-10-9-11(15)4-5-12(10)18-7-6-16-14(17)13-3-2-8-19-13/h2-5,8-9H,6-7H2,1H3,(H,16,17)
InChI key
RULQUKFOBAPKKR-UHFFFAOYSA-N
생화학적/생리학적 작용
Activator of K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channels
ML402 is a selective activator of K2P2.1 (TREK-1) and K2P10.1 (TREK-2) potassium channels. It was used to determine a cryptic selectivity filter binding site of the K2P2.1 (TREK-1) channel, designated the K2P modulator pocket. This binding pocket stabilizes an active "leak-mode" conformation, binding small-molecule activators that restrict the mobility of the selectivity filter and surrounding structure.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
Marco Lolicato et al.
Nature, 547(7663), 364-368 (2017-07-12)
Polymodal thermo- and mechanosensitive two-pore domain potassium (K2P) channels of the TREK subfamily generate 'leak' currents that regulate neuronal excitability, respond to lipids, temperature and mechanical stretch, and influence pain, temperature perception and anaesthetic responses. These dimeric voltage-gated ion channel
활성 필터
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