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Merck
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SML0136

Sigma-Aldrich

TGN-020

≥98% (HPLC)

동의어(들):

2-(Nicotinamide)-1,3,4-thiadiazole, N-(1,3,4-Thiadiazol-2-yl)-3-pyridinecarboxamide, N-(1,3,4-Thiadiazol-2-yl)pyridine-3-carboxamide, N-(1,3,4-Thiadiazolyl)-m-nicotinamide

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크기 선택

5 MG
₩288,666
25 MG
₩1,148,574

₩288,666

예상 입고일2025년 4월 14일세부사항

벌크 견적 요청
모든 사진(1)

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보기 변경
5 MG
₩288,666
25 MG
₩1,148,574

About This Item

실험식(Hill 표기법):
C8H6N4OS
CAS Number:
51987-99-6
Molecular Weight:
206.22
MDL number:
MFCD00708771
UNSPSC 코드:
12352200
PubChem Substance ID:
329825185
NACRES:
NA.77

₩288,666

예상 입고일2025년 4월 14일세부사항

벌크 견적 요청

분석

≥98% (HPLC)

양식

powder

색상

white to tan

solubility

DMSO: ≥8 mg/mL

저장 온도

room temp

SMILES string

O=C(Nc1nncs1)c2cccnc2

InChI

1S/C8H6N4OS/c13-7(6-2-1-3-9-4-6)11-8-12-10-5-14-8/h1-5H,(H,11,12,13)

InChI key

AGEGZHOPKZFKBP-UHFFFAOYSA-N

애플리케이션

Beas2B human lung epithelial cells were treated with TGN-020 to study the effect on cigarette smoke extracts-induced CCN1 secretion.[1]

생화학적/생리학적 작용

Aquaporin 4 (AQP4) inhibitor
TGN-020 is an inhibitor of Aquaporin 4 (AQP4), the most abundant water channel in brain. Aquaporins (AQPs) are water channels required for maintaining fluid homeostasis and enabling water movement across barrier membranes, but can enhance pathological cellular volume changes and cause edema in injury states. Pretreatment with the AQP4 inhibitor TGN-020 significantly reduced the volume of brain edema associated with ischemic injury in a mouse model of focal cerebral ischemia.

픽토그램

Exclamation mark
GHS07

신호어

Warning

유해 및 위험 성명서

H302

예방조치 성명서

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
0000442631
0000442628
0000442628
0000442631
0000405922

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특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

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문서 라이브러리 방문

Jian Li et al.
Brain research bulletin, 170, 162-173 (2021-02-17)
The extracellular signal-regulated kinase (ERK) pathway has been reported to play a pivotal role in mediating spinal cord injury (SCI) progression. The present study aimed to investigate the effects of phosphorylated ERK1/2 (p-ERK1/2) inhibition on SCI-induced astrocyte activation and inflammation
Maosheng Xia et al.
Psychopharmacology, 234(3), 365-379 (2016-11-12)
Many studies have indicated that a history of depression increases the risk of developing Alzheimer's disease (AD); however, the potential pathogenestic mechanism by which depression functions as a high risk factor for AD remains unknown. Recently, a "cerebral lymphatic system"
Dervis Dasdelen et al.
Mini reviews in medicinal chemistry, 20(6), 498-512 (2019-10-28)
In the literature screening, aquaporins were found in the cerebral structures including the pia mater, choroid plexus, ependyma, piriform cortex, hippocampus, dorsal thalamus, supraoptic and suprachiasmatic nuclei, white matter and subcortical organ. Among these, the most common are AQP1, AQP4
Yuji Suzuki et al.
Neurosurgery, 82(6), 842-846 (2017-06-25)
Aquaporin (AQP) water channels play a significant role in mesenchymal microvascular proliferation and infiltrative growth. AQPs are highly expressed in malignant astrocytomas, and a positive correlation is observed between their expression levels and histological tumor grade. To examine the utility
Cheng Guo et al.
Inflammation, 42(4), 1401-1412 (2019-04-05)
Acute lung injury (ALI) is a syndrome characterized by damage to the alveolar-capillary wall, pulmonary edema and recruitment of inflammatory cells. Previous studies have indicated that aquaporin 4 (AQP4) plays a key role in brain edema formation and resolution. However
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질문

  1. We purchased a quantity of TGN-020 earlier this year but have had exceptional difficulty finding an effective solvent for this compound (tried DCM and H2O). Does Sigma-Aldrich have data on compatible solvents? Primary lit hasn't been helpful. Thanks!

    1 답변

    1. The solubility specification for this product is >/= 8mg/mL in DMSO. The rate may be higher and is lot-specific, however, the minimum concentration in DMSO is 8 mg/mL. A brief literature search shows that HCl, Ethanol, and Dimethylformamide have also been used to dissolve this compound.
      Please see the sample Certificate of Analysis for example:
      https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/SML0136-5MG0000258843.pdf

      If solubility issues continue, we kindly ask you to navigate to the link https://www.sigmaaldrich.com/techservice, and click on "Report Product Issues" under the Products Section with all the required information so that a member of our team can reach out to you to assist further. Thank you.

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