N3876

(−)-Nicotine

≥99% (GC), liquid

• 동의어(들): (−)-1-Methyl-2-(3-pyridyl)pyrrolidine, (S)-3-(1-Methyl-2-pyrrolidinyl)pyridine
• 실험식(Hill 표기법): C₁₀H₁₄N₂
• CAS Number: 54-11-5
• Molecular Weight: 162.23
• Beilstein: 82109
• EC Number: 200-193-3
• MDL number: MFCD00006369
• UNSPSC 코드: 12352210
• PubChem Substance ID: 24897663
• NACRES: NA.77

속성

• Quality Level: 200
• 분석: ≥99% (GC)
• 형태: liquid
• 광학 활성: [α]20/D −169°(lit.)
• 색상: yellow
• refractive index: n20/D 1.5265 (lit.)
• solubility: ethanol: 50 mg/mL
• density: 1.010 g/mL at 20 °C (lit.)
• SMILES string: CN1CCC[C@H]1c2cccnc2
• InChI: 1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1
• InChI key: SNICXCGAKADSCV-JTQLQIEISA-N
• 유전자 정보: human ... CHRNA2(1135) , CHRNA3(1136) , CHRNA4(1137) , CHRNB2(1141) , CHRNB4(1143) , CYP2A6(1548) , KCNH1(3756) ; mouse ... Chrna7(11441) , Chrnb1(11443) ; rat ... Chrna1(79557) , Chrna2(170945) , Chrna4(25590) , Chrna7(25302) , Chrnb2(54239) , Chrnb4(25103)

설명

일반 설명

Nicotine is the most abundant alkaloid found in the leaves of Nicotiana species. It is a major toxic agent.

애플리케이션

(-)-Nicotine has been used:

• to stimulate neutrophils in extracellular DNA fluorescence assay and in immunostaining of neutrophils
• to study the effects of chronic neonatal nicotine exposure on nicotinic acetylcholine receptor (nAChR) binding, cell death and morphology in hippocampus and cerebellum
• in an in vitro study to evaluate the effect of root exposure to nicotine or cotinine on the morphology and density of fibroblasts

생화학적/생리학적 작용

Nicotine binds to nicotinic acetylcholine receptors and exhibit both neuroprotective and neurotoxic effects on the developing brain. It is associated with lung cancer development and reduces the efficiency of chemotherapeutic agents. In addition, nicotine has an ability to impair phagocytic host defense and also increase reactive oxygen species (ROS) associated injury. It also stops Akt/ protein kinase B (PKB) deactivation and decreases spontaneous death of neutrophils. Nicotine is used to treat Alzheimer′s and Parkinson′s disease.

Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.

안전성 정보

• 픽토그램: GHS06,GHS05,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H300 + H310 + H330,H315,H318,H411
• 예방조치 성명서: P262 - P273 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 1 Oral - Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): 213.8 °F - closed cup
• Flash Point (°C): 101 °C - closed cup
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter