추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen 23 kDa
종 반응성
human
농도
~1 mg/mL
기술
ELISA: 1:10000
western blot: 1:500-1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... APOBEC3A(200315)
일반 설명
APOBEC3A (apolipoprotein B mRNA editing enzyme catalytic subunit 3A) belongs to the AID/APOBEC family of enzymes. It is located on human chromosome 22q13.1.
Anti-APOBEC3A antibody detects endogenous levels of total APOBEC3A protein.
면역원
The antiserum was produced against synthesized peptide derived from human APOBEC3A.
Immunogen Range: 27-76
Immunogen Range: 27-76
애플리케이션
Anti-APOBEC3A antibody has been used in western blotting.
생화학적/생리학적 작용
APOBEC3A (apolipoprotein B mRNA editing enzyme catalytic subunit 3A) deaminates methylated cytosine bases in DNA. It is considered as a viral DNA mutator and performs broad antiviral activity.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Jan-Hendrik Bockmann et al.
The Journal of infectious diseases, 220(4), 567-577 (2019-03-30)
Type III interferons (IFNs) (λ1-3) activate similar signaling cascades as type I IFNs (α and β) via different receptors. Since IFN-α and lymphotoxin-β activate cytosine deamination and subsequent purging of nuclear hepatitis B virus (HBV) DNA, we investigated whether IFN-β
APOBEC3A efficiently deaminates methylated, but not TET-oxidized, cytosine bases in DNA
Schutsky EK, et al.
Nucleic Acids Research, 45(13), 7655-7665 (2017)
Heat Increases the Editing Efficiency of Human Papillomavirus E2 Gene by Inducing Upregulation of APOBEC3A and 3G
Yang Y, et al.
The Journal of Investigative Dermatology, 137(4), 810-818 (2017)
Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A
Aynaud MM, et al.
The Journal of Biological Chemistry (2012)
Marie-Ming Aynaud et al.
The Journal of biological chemistry, 287(46), 39182-39192 (2012-09-15)
The human polydeoxynucleotide cytidine deaminases APOBEC3A, APOBEC3C, and APOBEC3H are capable of mutating viral DNA in the nucleus, whereas APOBEC3A alone efficiently edits nuclear DNA. Deamination is rapidly followed by excision of uracil residues and can lead to double-stranded breaks.
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