The GOT2 (glutamic-oxaloacetic transaminase 2) gene is mapped to human chromosome 16q21 and the encoded protein is localized to mitochondria.
면역원
Peptide with sequence CKDADEAKRVES from the internal region of the protein sequence according to NP_002071.2.
생화학적/생리학적 작용
GOT2 (glutamic-oxaloacetic transaminase 2) participates in malate–aspartate shuttle, which increases the rate of glycolysis via cytosolic NADH (nicotinamide adenine dinucleotide) transfer into mitochondria. This supports rapid growth in tumor cell. GOT2 catalyzes the transamination reaction involving oxaloacetate and L-glutamate to give rise to aspartate, also generating α-ketoglutarate in mitochondria. Aspartate, that is formed, serves as a precursor of N-acetylaspartate, a predominantly abundant free amino acid found in the brain.
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물리적 형태
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
World journal of gastroenterology, 21(3), 711-725 (2015-01-28)
For several decades, serum levels of alanine (ALT) and aspartate (AST) aminotransferases have been regarded as markers of liver injury, including a wide range of etiologies from viral hepatitis to fatty liver. The increasing worldwide prevalence of metabolic syndrome and
The malate-aspartate shuttle is indispensable for the net transfer of cytosolic NADH into mitochondria to maintain a high rate of glycolysis and to support rapid tumor cell growth. The malate-aspartate shuttle is operated by two pairs of enzymes that localize
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