S0278
(±)-Sotalol hydrochloride
≥98% (TLC), powder, β-Adrenoceptor antagonist
동의어(들):
N-[4-[1-Hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide hydrochloride
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모든 사진(2)
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25 MG
₩221,981
100 MG
₩535,311
About This Item
실험식(Hill 표기법):
C12H20N2O3S · HCl
CAS Number:
Molecular Weight:
308.82
EC Number:
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
제품명
(±)-Sotalol hydrochloride, ≥98% (TLC), powder
Quality Level
분석
≥98% (TLC)
양식
powder
색상
white to off-white
solubility
H2O: 20 mg/mL
주관자
Bayer
SMILES string
Cl.CC(C)NCC(O)c1ccc(NS(C)(=O)=O)cc1
InChI
1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H
InChI key
VIDRYROWYFWGSY-UHFFFAOYSA-N
유전자 정보
human ... ADRB1(153) , ADRB2(154) , ADRB3(155) , KCNH2(3757)
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애플리케이션
생화학적/생리학적 작용
Potent β-adrenoceptor antagonist; class III antiarrhythmic; prolongs the action potential and increases the refractory period.
Sotalol has a potential to block non-cardioselective β-adrenergic receptors. It acts as an anti-arrhythmic agent and is used as a therapeutic for equine arrhythmias. In addition, sotalol also has an ability to stop atrial fibrillation recurrence.[3]
특징 및 장점
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
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시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Differential Free Intracellular Calcium Release by Class II Antiarrhythmics in Cancer Cell Lines
Reyes-Corral M, et al.
Journal of Pharmacology and Experimental Therapeutics, 369(1), 152-162 (2019)
Alexander Burashnikov et al.
Circulation. Arrhythmia and electrophysiology, 5(2), 400-408 (2012-02-11)
Several clinical trials have shown that vernakalant is effective in terminating recent onset atrial fibrillation (AF). The electrophysiological actions of vernakalant are not fully understood. Here we report the results of a blinded study comparing the in vitro canine atrial
Kyle A Arsenault et al.
The Cochrane database of systematic reviews, 1(1), CD003611-CD003611 (2013-02-27)
Atrial fibrillation is a common post-operative complication of cardiac surgery and is associated with an increased risk of post-operative stroke, increased length of intensive care unit and hospital stays, healthcare costs and mortality. Numerous trials have evaluated various pharmacological and
László Drimba et al.
Journal of cardiovascular pharmacology, 60(2), 208-218 (2012-05-25)
High-fat diet and consequent metabolic syndrome (MS) can lead to elevated risk for cardiac arrhythmias. This preclinical study was to investigate if cicletanine (CIC) could produce cardioprotective effects in conscious rabbits exhibiting the main symptoms of MS. NZW rabbits that
Wei Liu et al.
Pharmaceutical research, 29(7), 1768-1774 (2012-02-22)
To clarify sotalol's classification in the BCS versus BDDCS systems through cellular, rat everted sac and PAMPA permeability studies. Studies were carried out in Madin Darby canine kidney (MDCK) and MDR1-transfected MDCK (MDCK-MDR1) cell lines, rat everted gut sacs and
문서
신경과학을 위한 생체 활성 저분자
DISCOVER Bioactive Small Molecules for Neuroscience
Chromatograms
application for HPLCapplication for HPLCapplication for HPLC활성 필터
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