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L7757

Sigma-Aldrich

Lidocaine

≥98% (GC), powder, neuroprotective agent

동의어(들):

2-Diethylamino-N-(2,6-dimethylphenyl)acetamide, Lignocaine, Xylocaine

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크기 선택

25 G
₩114,594
100 G
₩370,475

₩114,594

출고 가능일2025년 4월 09일세부사항

벌크 견적 요청
모든 사진(2)

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보기 변경
25 G
₩114,594
100 G
₩370,475

About This Item

실험식(Hill 표기법):
C14H22N2O
CAS Number:
137-58-6
Molecular Weight:
234.34
EC Number:
205-302-8
MDL number:
MFCD00026733
UNSPSC 코드:
12352200
PubChem Substance ID:
24896480
NACRES:
NA.77

₩114,594

출고 가능일2025년 4월 09일세부사항

벌크 견적 요청

제품명

Lidocaine, powder

양식

powder

SMILES string

CCN(CC)CC(=O)Nc1c(C)cccc1C

InChI

1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)

InChI key

NNJVILVZKWQKPM-UHFFFAOYSA-N

유전자 정보

human ... CYP1A2(1544) , SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)
rat ... Scnn1a(25122)

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일반 설명

Lidocaine is a local anesthetic and an effective antiarrhythmia agent.[1][2] It occurs as solutions of crystalline colorless solid for injections,[3] that has a short half-life within plasma.[4]

애플리케이션

Lidocaine may be used for drug testing[5] and for voltage clamp experiments.[6]

생화학적/생리학적 작용

Lidocaine, a neuroprotective agent, mediates blockage of sodium (Na+) channels.[2][4] It prevents the influx of sodium ions leading to depolarization of sodium channels[3] and metabolically inactivated in liver.[4] Lidocaine has positive effect on cerebral ischemia.[2] It is also used in the treatment of ventricular tachycardia.[4] Lidocaine is an efficient anesthetic agent in ophthalmic surgeries as it is highly potent and has good tissue penetrability.[7]
Na+ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration.
Na+ channel blocker; class IB antiarrhythmic.

픽토그램

Exclamation mark
GHS07

신호어

Warning

유해 및 위험 성명서

H302

예방조치 성명서

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
0000286319
0000286319
MKCV1175
MKCS8025
MKCN8542

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Pharmacokinetics and pharmacodynamics of lignocaine: a review
Weinberg L, et al.
World Journal of Anesthesiology, 4(2), 17-29 (2015)
Functional effects of the late sodium current inhibition by AZD7009 and lidocaine in rabbit isolated atrial and ventricular tissue and Purkinje fibre
Persson F, et al.
European Journal of Pharmacology, 558(1-3), 133-143 (2007)
A microfluidic gradient maker for toxicity testing of bupivacaine and lidocaine
Tirella A, et al.
Toxicology in vitro, 22(8), 1957-1964 (2008)
Neuroprotective effect of low-dose lidocaine in a rat model of transient focal cerebral ischemia
Lei B, et al.
Anesthesiology, 95(2), 445-451 (2001)
Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy (2008)
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질문

1–4 / 4 질문  

  1. How does the storage temperature relate to shipping conditions?

    1 답변

    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

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  2. What is the Department of Transportation shipping information for this product?

    1 답변

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  3. How do I dissolve lidocaine free base (Product No. L7757)?

    1 답변

    1. The product is soluble in alcohol, ether, benzene, chloroform and oils, according to the chemicals encyclopedia published by the Royal Society of Chemistry , 14th ed. online  (2006).  Lidocaine hydrochloride monohydrate (Product No. L5647) is soluble in water.  Since the lidocaine hydrochloride is so much more soluble than lidocaine free base, lowering the pH to that of the hydrochloride (pH 4.0-5.5) or to that of injectable forms (pH 5.0-7.0) should greatly enhance the solubility of L7757.

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  4. Is Product L7757, Lidocaine free base, suitable for use as a reference standard?

    1 답변

    1. No. We would recommend Product No. L1026 (Lidocaine, Sigma References Standard). The current lot is current with USP 31, 2nd Supplement, and is traceable to USP Reference Standard lot MOF220.

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