모든 사진(5)

문서

C1768

Cytarabine

Name: Cytarabine
Brand: SIGMA

≥90% (HPLC), crystalline, DNA replication inhibitor

동의어(들):

(β-D-Arabinofuranosyl)cytosine, Ara-C, Arabinocytidine, Arabinosylcytosine, Cytarabine, Cytosine arabinoside

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모든 사진(5)

About This Item

실험식(Hill 표기법):

C₉H₁₃N₃O₅

CAS Number:

147-94-4

Molecular Weight:

243.22

Beilstein:

89175

EC Number:

205-705-9

MDL number:

MFCD00066487

UNSPSC 코드:

12352200

PubChem Substance ID:

24892435

NACRES:

NA.77

추천 제품

Slide 1 of 10

1 of 10

Sigma-Aldrich

C6645

Cytosine β-D-arabinofuranoside hydrochloride

Sigma-Aldrich

B5002

5-Bromo-2′-deoxyuridine

Sigma-Aldrich

251010

1-β-D-Arabinofuranosylcytosine

Sigma-Aldrich

F0503

5-Fluoro-2′-deoxyuridine

Sigma-Aldrich

D9891

Doxycycline hyclate

Sigma-Aldrich

I7125

5-Iodo-2′-deoxyuridine

Sigma-Aldrich

C4706

Tris(2-carboxyethyl)phosphine hydrochloride

Sigma-Aldrich

L2020

Laminin from Engelbreth-Holm-Swarm murine sarcoma basement membrane

Sigma-Aldrich

S2002

Sodium azide

Sigma-Aldrich

P3655

Poly-L-ornithine hydrobromide

product name

Cytosine β-D-arabinofuranoside, crystalline, ≥90% (HPLC)

분석

≥90% (HPLC)

형태

crystalline

저장 온도

2-8°C

SMILES string

NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O

InChI

1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1

InChI key

UHDGCWIWMRVCDJ-CCXZUQQUSA-N

유전자 정보

human ... POLA1(5422) , POLA2(23649) , POLB(5423) , POLD1(5424) , POLD2(5425) , POLD3(10714) , POLD4(57804) , POLE(5426) , POLE2(5427) , POLE3(54107) , PRIM1(5557) , PRIM2(5558)
mouse ... Cda(72269)

유사한 제품을 찾으십니까? 방문 제품 비교 안내

생화학적/생리학적 작용

Ara-C incorporates into DNA and inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation; does not inhibit RNA synthesis. Anti-leukemia agent.

특징 및 장점

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

픽토그램

GHS08,GHS07

신호어

Warning

유해 및 위험 성명서

H317,H361fd

예방조치 성명서

P202 - P261 - P272 - P280 - P302 + P352 - P308 + P313

Hazard Classifications

Repr. 2 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

개인 보호 장비

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

이미 열람한 고객

Slide 1 of 3

1 of 3

Sigma-Aldrich

M7898

Monoclonal Anti-Thy 1.1 antibody produced in mouse

Sigma-Aldrich

U3750

Uridine

Sigma-Aldrich

N3641

4-Nitrophenyl α-L-arabinofuranoside

Antitumor studies. Part 1: design, synthesis, antitumor activity, and AutoDock study of 2-deoxo-2-phenyl-5-deazaflavins and 2-deoxo-2-phenylflavin-5-oxides as a new class of antitumor agents.

Hamed I Ali et al.

Bioorganic & medicinal chemistry, 15(1), 242-256 (2006-10-20)

Novel 2-deoxo-2-phenyl-5-deazaflavins and 2-deoxo-2-phenylflavin-5-oxides were prepared as a new class of antitumor agents and showed significant antitumor activities against NCI-H 460, HCT 116, A 431, CCRF-HSB-2, andKB cell lines. In vivo investigation, 2-deoxo-10-methyl-2-phenyl-5-deazaflavin exhibited the effective antitumor activity against A

Two dosing regimens of tosedostat in elderly patients with relapsed or refractory acute myeloid leukaemia (OPAL): a randomised open-label phase 2 study.

Jorge Cortes et al.

The Lancet. Oncology, 14(4), 354-362 (2013-03-05)

Tosedostat is a novel oral aminopeptidase inhibitor with clinical activity in a previous phase 1-2 study in elderly patients with relapsed or refractory acute myeloid leukaemia (AML). We aimed to compare two dosing regimens of tosedostat. In this randomised phase

Structure-activity relationship and molecular mechanisms of ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) and its analogues.

Sonia G Das et al.

Journal of medicinal chemistry, 54(16), 5937-5948 (2011-07-26)

Multidrug resistance (MDR) in cancer is a phenomenon in which administration of a single chemotherapeutic agent causes cross-resistance of cancer cells to a variety of therapies even with different mechanisms of action. Development of MDR against standard therapies is a

Sense and nonsense of high-dose cytarabine for acute myeloid leukemia.

Bob Löwenberg

Blood, 121(1), 26-28 (2013-01-05)

High-dose cytarabine applied during remission induction or as consolidation after attainment of a complete remission has become an established element in the treatment of adults with acute myeloid leukemia. Recent evidence has challenged the need for these exceptionally high-dose levels

SPP1 promotes Schwann cell proliferation and survival through PKCα by binding with CD44 and αvβ3 after peripheral nerve injury.

Jiang-Bo Wang et al.

Cell & bioscience, 10, 98-98 (2020-08-28)

Schwann cells (SCs) play a crucial role in Wallerian degeneration after peripheral nerve injury. The expression of genes in SCs undergo a series of changes, which greatly affect the proliferation and apoptosis of SCs as well as the fate of

모든 관련된 서류 보기

문서

DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

Bioactive Molecules for Apoptosis

Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.

세포 주기 연구를 위한 생체 활성 저분자

증식하는 세포에서 세포 주기는 4단계로 구성됩니다. Gap 1(G1)은 유사분열과 세포 성장을 특징으로 하는 DNA 복제 사이의 기간입니다. DNA 복제는 합성(S)기에 일어나며, 세포 분열을 위한 성장 및 준비를 하는 Gap 2(G2)가 뒤따릅니다. 이 세 단계는 함께 세포주기의 간기 단계를 구성합니다. 간기 이후에 분열(M)기가 뒤따릅니다.

Discover Bioactive Small Molecules for Cell Cycle

Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.

문서

Cytarabine

≥90% (HPLC), crystalline, DNA replication inhibitor

About This Item

추천 제품

속성

product name

분석

형태

저장 온도

SMILES string

InChI

InChI key

유전자 정보

설명

생화학적/생리학적 작용

특징 및 장점

안전성 정보

픽토그램

신호어

유해 및 위험 성명서

예방조치 성명서

Hazard Classifications

Storage Class Code

WGK

개인 보호 장비

문서

시험 성적서(COA)

이 제품을 이미 가지고 계십니까?

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