PZ0002

Maraviroc

≥98% (HPLC)

• 동의어(들): 4,4-Difluoro-N-[(1S)-3-[(3-exo)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl]cyclohexanecarboxamide, UK-427857
• 실험식(Hill 표기법): C₂₉H₄₁F₂N₅O
• CAS Number: 376348-65-1
• Molecular Weight: 513.67
• MDL number: MFCD13188530
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329823671
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 광학 활성: [α]-15/D
• 색상: white
• solubility: DMSO: >30 mg/mL
• 저장 온도: room temp
• SMILES string: CC(C)c1nnc(C)n1[C@H]2C[C@@H]3CC[C@H](C2)N3CC[C@H](NC(=O)C4CCC(F)(F)CC4)c5ccccc5
• InChI: 1S/C29H41F2N5O/c1-19(2)27-34-33-20(3)36(27)25-17-23-9-10-24(18-25)35(23)16-13-26(21-7-5-4-6-8-21)32-28(37)22-11-14-29(30,31)15-12-22/h4-8,19,22-26H,9-18H2,1-3H3,(H,32,37)/t23-,24+,25-,26-/m0/s1
• InChI key: GSNHKUDZZFZSJB-QYOOZWMWSA-N
• 유전자 정보: human ... CCR5(1234)

설명

애플리케이션

Maraviroc has been used as a C-C chemokine receptor type 5 (CCR5-specific) inhibitor in murine monocyte/macrophage cell line J774A.1,[1] porcine uterine luminal epithelial cells[2] and human lung CD4⁺ T cells.[3]

생화학적/생리학적 작용

Maraviroc is a CCR5 chemokine receptor antagonist and antiretroviral entry inhibitor.

Maraviroc is a CCR5 chemokine receptor antagonist, and antiretroviral entry inhibitor. Maraviroc inhibits HIV entry by blocking interaction of viral coat protein gp120 with the receptor.

Maraviroc is metabolised by cytochrome P450 3A4. The transport and absorption of maraviroc in the intestine and bile is regulated by P-glycoprotein (Pgp).[4] Maraviroc binds to the active site pocket of chemokine receptor CCR5 making the receptor inactive.[5]

특징 및 장점

This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable