227016

CCR2 Antagonist

≥97% (racemic mixture, HPLC), solid, CCR2 antagonist, Calbiochem^®

• 동의어(들): CCR2 Antagonist, 2-((Isopropylaminocarbonyl)amino)-N-(2-((cis-2-((4-(methylthio)benzoyl)amino)cyclohexyl)amino)-2-oxoethyl)-5-(trifluoromethyl)-benzamide, CC Chemokine Receptor 2 Antagonist
• 실험식(Hill 표기법): C₂₈H₃₄F₃N₅O₄S
• CAS Number: 445479-97-0
• Molecular Weight: 593.66
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• product name: CCR2 Antagonist, The CCR2 Antagonist, also referenced under CAS 445479-97-0, controls the biological activity of CCR2.
• Quality Level: 100
• 분석: ≥97% (racemic mixture, HPLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic); protect from light
• 색상: white
• solubility: ethanol: 6 mg/mL; DMSO: 60 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C

설명

일반 설명

A cis-diamidocyclohexyl urea compound that potently competes against MCP-1 binding to CCR2 (IC₅₀ = 5.1 nM) and effectively inhibits MCP-1/CCR2-mediated PBMCs Ca⁺² flux and chemotaxis (IC₅₀ = 18 and 1 nM, respectively), while showing much less effect against eotaxin binding to CCR3 (37% inhibition at 10 µM). Mutageneis analysis indicates CCR2 Thr292 is critical in maintaining the high affinity antagonist binding.

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

제조 메모

Gentle warming, rapid stirring, and/or sonication may be required for complete solubilization.

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Cherney, R.J., et al. 2008. J. Med. Chem.51, 721.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable