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Merck
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주요 문서

P9389

Sigma-Aldrich

Poly(deoxyguanylic-deoxycytidylic) acid sodium salt

double stranded, alternating copolymer

동의어(들):

Poly(dG-dC) • Poly(dG-dC)

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모든 사진(1)

About This Item

CAS Number:
90385-88-9
MDL number:
MFCD00131968
UNSPSC 코드:
41106305
NACRES:
NA.51
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생물학적 소스

synthetic (organic)

Quality Level

200

양식

powder or solid

저장 온도

−20°C

일반 설명

Poly(deoxyguanylic-deoxycytidylic) acid (poly(dG-dC)) undergoes salt dependent conformational transition. Under high-salt, it exists as a left-handed double helix and at low-salt it displays B-DNA conformation.[1] However on immobilization, poly(dG-dC) takes up A DNA form.[2]

애플리케이션

Poly(deoxyguanylic-deoxycytidylic) acid (Poly(dG-dC) • Poly(dG-dC)) is an alternating copolymer, self-complementary, double-stranded DNA model for conformational studies of DNA structure dynamics and drug interaction.
Poly(deoxyguanylic-deoxycytidylic) acid sodium salt has been used:
  • in electrophoretic mobility shift assay of transcription factor IIIB complex[3]
  • as synthetic copolymers for circular dichroism (CD) spectroscopy studies[4]
  • as a positive control in liquid scintillation counting[5]

기타 정보

Alternating copolymer; self-complementary, form double-stranded complex

단위 정의

One unit will yield an A260 of 1.0 in 1.0 ml 20 mM sodium phosphate/100 mM NaCl, pH 7.0 (1cm light path).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number
0000393456
0000342261
0000393456
0000342261
SLCN5076

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문서 라이브러리 방문

Poly (dG)-poly (dC) DNA appears shorter than poly (dA)-poly (dT) and possibly adopts an A-related conformation on a mica surface under ambient conditions
Borovok N, et al.
Febs Letters, 581(30), 5843-5846 (2007)
TFIIIB subunit locations on U6 gene promoter DNA mapped by site-specific protein-DNA photo-cross-linking
Kang JJ, et al.
Febs Letters, 590(10), 1488-1497 (2016)
Genomic DNA methylation decreases in response to moderate folate depletion in elderly women-
Rampersaud GC, et al.
American Journal of Clinical Nutrition, 72(4), 998-1003 (2000)
Salt-dependent dynamic structure of poly (dG-dC) textperiodcentered poly (dG-dC)
Ramstein J and Leng M
Nature, 288(5789), 413-413 (1980)
Ville Laitala et al.
Analytical chemistry, 77(5), 1483-1487 (2005-03-01)
We report here a novel, time-resolved, lanthanide-based energy-transfer assay utilizing nonoverlapping acceptor fluorophores, which have their absorption energetically at a higher level than the emittive transitions of the donor. The technique was studied by comparing a series of nonoverlapping acceptors
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