MAK422

ACE1 Inhibitor Screening Kit (Colorimetric)

sufficient for 100 colorimetric tests

• UNSPSC 코드: 12161503

속성

• 검출 방법: colorimetric
• 관련 질환(들): endocrinological disorders, diabetes; cardiovascular diseases; neurological disorders
• 저장 온도: −20°C

설명

일반 설명

Angiotensin-I-converting enzyme (ACE) is a peptidyl dipeptidase that catalyzes the conversion of decapeptide angiotensin I to octapeptide angiotensin II, by removing a carboxy-terminal dipeptide. ACE is a key part of the renin angiotensin system that regulates blood pressure. ACE inhibitor inhibits ACE1 enzymatic activity and decreases the production of angiotensin II. As a result, blood vessels are dilated thereby increasing the amount of blood pumped by the heart and lowering the blood pressure. ACE inhibitors are used for treating hypertension, heart failure, stroke etc. Recent research is also focused on the discovery of natural products as ACE1 Inhibitors.

특징 및 장점

ACE1 Inhibitor Screening Kit:

• Compatible with high-throughput handling systems.

적합성

The kit is suitable for the screening/characterizing of ACE1 inhibitors.

원리

The ACE1 Inhibitor Screening Kit can be used to screen potential ACE1 inhibitors. The kit utilizes the ability of an active ACE1 to hydrolyze a synthetic substrate, which results in the decrease in A₃₄₅ nm. In the presence of Captopril, an ACE1 specific inhibitor, the ACE1 enzymatic activity is greatly reduced and there is no significant decrease in the A₃₄₅ nm. The assay kit provides a rapid, simple and reliable test for high-throughput screening of ACE1 inhibitors.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H360F
• 예방조치 성명서: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects