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The milligram quantity of this product will vary from lot to lot. The vial content is dependent upon the protein content and enzymatic activity. The minimum protein content will be 70% and the minimum activity will be 2 units per milligram protein. As an example, a batch that reports a protein content of 100% and an activity of 2 units per milligram protein will have a vial content of 2.5 mg for the 5 unit package size. The protein content and activity are reported in the product Certificate of Analysis. Please see the link below to review a sample or lot specific Certificate:
https://www.sigmaaldrich.com/product/sigma/a6778#product-documentation
A6778
Angiotensin Converting Enzyme from rabbit lung
≥2.0 units/mg protein (modified Warburg-Christian)
동의어(들):
ACE, Peptidyl-dipeptidase A, Peptidyldipeptide Hydrolase
로그인조직 및 계약 가격 보기
크기 선택
0.1 UNIT
₩176,915
0.25 UNIT
₩342,360
1 UNIT
₩936,338
2 UNITS
₩1,914,189
5 UNITS
₩3,938,099
모든 사진(1)
크기 선택
보기 변경
0.1 UNIT
₩176,915
0.25 UNIT
₩342,360
1 UNIT
₩936,338
2 UNITS
₩1,914,189
5 UNITS
₩3,938,099
About This Item
CAS Number:
MDL number:
UNSPSC 코드:
12352204
eCl@ss:
42010109
NACRES:
NA.32
추천 제품
일반 설명
The angiotensin-converting enzyme (ACE) is a dipeptidyl-carboxypeptidase which exists in somatic and testicular isoforms with zinc binding motif HEXXH in their active site.[1] ACE regulates blood pressure through renin-angiotensin system. ACE elevates blood pressure by converting angiotensin I to a key vasoconstrictor angiotensin II and inhibiting a potent vasodilator bradykinin. Inhibition of ACE is a targeted therapeutic strategy for high blood pressure.[2][3] Several ACE synthetic inhibitory peptides available for clinical use include captopril, enalapril and lisinopril.[2] Currently, developing inhibitory peptides from natural food sources,[2][3][4] or phenolic compounds from plant sources to inhibit ACE is underway.[5] ACE plays a critical role in fertilization by releasing the proteins anchored to glycosylphosphatidylinositol (GPI) in sperm membrane.[1]
애플리케이션
Angiotensin converting enzyme from rabbit lung has been used:
- for measuring inhibitory effect of egg white protein hydrolysates on ACE activity by high performance liquid chromatography (HPLC)[2]
- to measure the ACE inhibition by litchi pericarp[5] and cooked chicken breast[4] using hippuryl-L-histidyl-L-leucine (HHL) as substrate by reverse phase-HPLC (RP-HPLC)3 and HPLC[4] respectively
- in releasing GPI anchored protein in vitro in few cell lines like HeLa, HEK293 and in vivo in mice sperm.[1]
생화학적/생리학적 작용
Removes C-terminal dipeptides from susceptible substrates, e.g., angiotensin I and bradykinin.
품질
May contain traces of sodium chloride.
단위 정의
One unit will produce 1.0 μmole of hippuric acid from Hippuryl-His-Leu per min in 50 mM HEPES and 300 mM NaCl at pH 8.3 at 37 °C.
신호어
Danger
유해 및 위험 성명서
예방조치 성명서
Hazard Classifications
Resp. Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Isolation and identification of angiotensin-converting enzyme inhibitory peptides from egg white protein hydrolysates
Liu J, et al.
Food Chemistry, 122(4), 1159-1163 (2010)
Yating Lu et al.
Journal of Zhejiang University. Science. B, 22(7), 575-589 (2021-07-17)
The aim of this work is to discover the inhibitory mechanism of tea peptides and to analyse the affinities between the peptides and the angiotensin-converting enzyme (ACE) as well as the stability of the complexes using in vitro and in
Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization
Kondoh G, et al.
Nature Medicine, 11(2), 160-166 (2005)
Mina Ojaghi et al.
Molecular reproduction and development, 84(5), 376-388 (2017-03-01)
We hypothesized that the testis-specific isoform of angiotensin-converting enzyme (tACE) is released during bovine sperm capacitation, and its peptidase activity is required for capacitation. Specific objectives of this study were to (i) develop an anti-tACE antibody; (ii) characterize expression of
Angiotensin converting enzyme (ACE) inhibitory peptides derived from the simulated in vitro gastrointestinal digestion of cooked chicken breast
Sangsawad P, et al.
Journal of functional foods, 29, 77-83 (2017)
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How many grams per 1 U?
1 답변-
도움이 되었습니까?
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What is the Department of Transportation shipping information for this product?
1 답변-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
도움이 되었습니까?
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What is the effect of bleomycin on Angiotensin Converting Enzyme (ACE) activity in vivo?
1 답변-
Bleomycin causes a marked reduction in rabbit lung ACE activity. Reference: Cancer Research, 40, 3621-3626, (1980).
도움이 되었습니까?
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Are there any other known inhibitors of rabbit lung Angiotensin Converting Enzyme (ACE), Product A6778?
1 답변-
Idrapril, the prototype of a new class of angiotensin converting enzyme (ACE) inhibitors, competitively inhibits, with nanomolar apparent Ki, the hydrolysis of hippuryl-glycyl-glycine by rabbit lung ACE. Kinetic Ki and kon and koff values were 470 pM, 3.0±1.5×106 M-1sec-1 and 1.4±0.3×10-3 sec-1, respectively. Reference: Biochemical Pharmacology, 45(6), 1358-1362 (1993).
도움이 되었습니까?
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What is the medical significance of Angiotensin Converting Enzyme (ACE), Product A6778?
1 답변-
Angiotensin-converting enzyme (ACE) produces angiotensin II, a substance that affects the cardiovascular system in numerous ways, including narrowing of blood vessels. This narrowing can cause high blood pressure and cause the heart to work harder. ACE inhibitors treat a variety of conditions, such as high blood pressure, scleroderma and migraines. (Mayo Clinic)
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