MAK202

Cathepsin S Inhibitor Screening Kit

Sufficient for 100 Fluorometric tests

• 동의어(들): CTSS Inhibitor Assay Kit
• UNSPSC 코드: 12352200

속성

• 검출 방법: fluorometric
• 관련 질환(들): endocrinological disorders, diabetes; cardiovascular diseases; cancer
• 저장 온도: −20°C
• 유전자 정보: human ... CTSS(1520) ; mouse ... CTSS(13040) ; rat ... CTSS(50654)

설명

일반 설명

Cathepsin S (CTSS; EC 3.4.22.27) is a lysosomal cysteine proteinase involved in the degradation of proteins to peptides required for the presentation of MHC class II molecules.1 It is associated with pathological conditions such as atherosclerosis, coronary heart disease, cancer, and insulin resistance.

적합성

Suitable for the screening of inhibitors of Cathepsin S.

원리

The Cathepsin S Inhibitor Screening Kit is a simple assay for screening potential inhibitors of CTSS. CTSS activity is measured by cleaving a synthetic 7-amino-4-trifluoromethylcoumarin (AFC)-based substrate to yield AFC, a fluorescent product (λ_ex = 400/ λ_em = 505 nm), proportional to the enzymatic activity present.

키트 구성품 전용

• CTSS Reaction Buffer
• Cathepsin S, human
• CTSS Substrate, Z-VVR-AFC, 10 mM
• CTSS Inhibitor Z-FF-FMK, 1 mM

안전성 정보

• Storage Class Code: 10 - Combustible liquids