M5525
4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester
≥98%, powder
동의어(들):
N-Succinimidyl 4-(maleimidomethyl)cyclohexanecarboxylate, SMCC
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모든 사진(2)
About This Item
실험식(Hill 표기법):
C16H18N2O6
CAS Number:
Molecular Weight:
334.32
Beilstein:
1555271
MDL number:
UNSPSC 코드:
12352103
PubChem Substance ID:
NACRES:
NC.07
추천 제품
분석
≥98%
형태
powder
반응 적합성
reagent type: linker
mp
180-182 °C (lit.)
solubility
chloroform: 50 mg/mL
DMF: soluble
작용기
NHS ester
배송 상태
wet ice
저장 온도
−20°C
SMILES string
O=C(ON1C(CCC1=O)=O)C2CCC(CN3C(C=CC3=O)=O)CC2
InChI
1S/C16H18N2O6/c19-12-5-6-13(20)17(12)9-10-1-3-11(4-2-10)16(23)24-18-14(21)7-8-15(18)22/h5-6,10-11H,1-4,7-9H2
InChI key
JJAHTWIKCUJRDK-UHFFFAOYSA-N
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일반 설명
4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester (SMCC) is a heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). SMCC contains nine atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers.
애플리케이션
4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester (SMCC) is useful for the preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. It has been used for the coupling of a peptide sequence to an amino group.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
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