모든 사진(1)
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5 MG
₩193,967
25 MG
₩599,155
About This Item
실험식(Hill 표기법):
C20H16N2O6
CAS Number:
Molecular Weight:
380.35
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
off-white to light tan
solubility
DMSO: ≥20 mg/mL
저장 온도
2-8°C
SMILES string
Oc1cccc(C(=O)Nc2cccc(NC(=O)c3cccc(O)c3O)c2)c1O
InChI
1S/C20H16N2O6/c23-15-8-2-6-13(17(15)25)19(27)21-11-4-1-5-12(10-11)22-20(28)14-7-3-9-16(24)18(14)26/h1-10,23-26H,(H,21,27)(H,22,28)
InChI key
MIQUEZGHEJGPJB-UHFFFAOYSA-N
관련 카테고리
애플리케이션
생화학적/생리학적 작용
MST-312 is a telomerase Inhibitor.
MST-312 is a telomerase Inhibitor. Telomeres are nucleoprotein complexes present on the ends of chromosomes, containing DNA segment tandem repeats that shorten with each repetitive cell cycle. Telomere shortening leads to loss of function, resulting in cell senescence and limited survivability. The reverse transcriptase, telomerase, maintains telomere length and function in immortalized cell lines and most cancer cell lines, and telomerase activity is associated with tumorigenesis. Telomere elongation is also believed to be an important contributor to the genomic stability and indefinite self renewal of iPS cells. 1 μM MST-312 was shown to effectively reduce telomere length and inhibit proliferation in U937 cells.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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이미 열람한 고객
Salinomycin abolished STAT3 and STAT1 interactions and reduced telomerase activity in colorectal cancer cells.
Chung SS, et al.
Anticancer Research, 37(2), 445-453 (2017)
Laurent Lacroix et al.
Nucleic acids research, 39(4), e21-e21 (2010-11-26)
RNA and DNA guanine-rich sequences can adopt unusual structures called Guanine quadruplexes (G4). A quadruplex-prone RNA sequence is present at the 5'-end of the 451-nt-long RNA component of telomerase, hTERC. As this quadruplex may interfere with P1 helix formation, a
Combination treatment with flavonoid morin and telomerase inhibitor MST-312 reduces cancer stem cell traits by targeting STAT3 and telomerase.
Chung SS, et al.
International Journal of Oncology, 49(2), 487-498 (2016)
Leili Saeednejad Zanjani et al.
Frontiers in oncology, 9, 1302-1302 (2020-01-11)
Cancer stem cells (CSCs) are a theorized small subpopulation of cells within tumors thought to be responsible for metastasis, tumor development, disease progression, treatment-resistance, and recurrence. The identification, isolation, and biological characterization of CSCs may therefore facilitate the development of
Ponmathi Panneerpandian et al.
Antiviral research, 174, 104695-104695 (2019-12-18)
Yin Yang 1 (YY1) is a ubiquitous transcription factor with both transcriptional activating and repressing functions. Targeting YY1 is considered as a potential therapeutic strategy for several malignancies. Telomerase Reverse Transcriptase (TERT) is also considered as a potential target for
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