추천 제품
분석
≥98% (HPLC)
양식
solid
약물 제어
regulated under CDSA - not available from Sigma-Aldrich Canada
solubility
DMSO: >5 mg/mL
저장 온도
2-8°C
SMILES string
O=C1NC(=S)NC(=O)C1C(=O)Nc2ccccc2
InChI
1S/C11H9N3O3S/c15-8(12-6-4-2-1-3-5-6)7-9(16)13-11(18)14-10(7)17/h1-5,7H,(H,12,15)(H2,13,14,16,17,18)
InChI key
JARCFMKMOFFIGZ-UHFFFAOYSA-N
관련 카테고리
애플리케이션
Merbarone has been used to study its effect on the occurrence of DNA lesions.[1]
생화학적/생리학적 작용
Selective topoisomerase II inhibitor. Blocks topo II-mediated DNA cleavage without stabilizing DNA-topo II-cleavable complexes. Induces apoptosis in CEM cells via caspase 3 dependent mechanism.
Thiobarbituric acid with aniline joined by an amide linkage forms merbarone.[2] It is known to prolong cell cycle progression by inducing DNA double strand breaks, retarding S phase and arresting G2 phase.[3][4] This delays cell entry into mitosis.[3] Merbarone possesses cytotoxic and genotoxic action and promotes endoreduplication.[4] Merbarone has mild antitumor action and is also found to nephrotoxic.[2]
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
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시험 성적서(COA)
Lot/Batch Number
U R Malik et al.
Medical oncology (Northwood, London, England), 14(3-4), 159-162 (1998-02-19)
The standard treatment for patients with primary malignant glioma includes surgical resection, radiotherapy, and nitrosourea. Despite this multimodality approach, adults with newly diagnosed glioblastoma multiforme (GBM) and high-grade astrocytoma have a median survival duration of 50 weeks and 150 weeks
Ling Wang et al.
Mutation research, 616(1-2), 70-82 (2006-12-19)
Merbarone, a topoisomerase II (topo II) inhibitor which, in contrast to etoposide, does not stabilize topo II-DNA cleavable complexes, was previously shown to be a potent clastogen in vitro and in vivo. To investigate the possible mechanisms, we compared the
Nuria Pastor et al.
Mutation research, 738-739, 45-51 (2012-08-28)
In the last years a number of reports have shown that the so-called topoisomerase II (topo II) catalytic inhibitors are able to induce DNA and chromosome damage, an unexpected result taking into account that they do not stabilize topo II-DNA
Y Y Mo et al.
Cancer research, 57(22), 5004-5008 (1997-11-26)
DNA topoisomerase II (topo II) is a target for many clinically useful anticancer drugs. However, a major concern in the use of these drugs is the development of resistance, often manifested by reduced drug accumulation or reduced topo IIalpha activity
Frontiers in Anti-Cancer Drug Discovery, 3, 21-21 (2014)
문서
Agents reported to activate cellular caspases include chemotherapeutic drugs, TNF receptor agonists, and other enzymes. Inhibitors of apoptosis were the first identified endogenous caspase inhibitors.
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