M0252

Methylglyoxal solution

~40% in H₂O

• 동의어(들): Acetylformaldehyde, Pyruvaldehyde, Pyruvic aldehyde
• Linear Formula: CH₃COCHO
• CAS Number: 78-98-8
• Molecular Weight: 72.06
• Beilstein: 906750
• MDL number: MFCD00006960
• UNSPSC 코드: 12352204
• PubChem Substance ID: 24896540
• NACRES: NA.32

속성

• 형태: liquid
• 농도: ~40% (enzymatic); ~40% in H₂O
• density: 1.17 g/mL at 25 °C (lit.)
• 저장 온도: 2-8°C
• SMILES string: [H]C(=O)C(C)=O
• InChI: 1S/C3H4O2/c1-3(5)2-4/h2H,1H3
• InChI key: AIJULSRZWUXGPQ-UHFFFAOYSA-N

설명

일반 설명

Methylglyoxal (MG) is a glucose metabolite, which is linked to peripheral neuropathy and pain in diabetic patients. It enhances intracellular calcium in sensory neurons and produces behavioral nociception. Methylglyoxal has antibacterial property. MG functions as a protein-glycating agent and precursor of advanced glycation end products. It impairs diabetic wound healing.

애플리케이션

Methylglyoxal solution has been used:

• to assess glyoxalase 1 (GLO1) enzymatic activity
• as an advanced glycation end (AGE) forming agent for the preparation of albumin in vitro
• to regulate anxiety like behavior in mice
• to induce peritoneal fibrosis in rats
• to study the chromatographic retention characteristics of organic chemicals and metal DNA adducts
• for intraplantar injection in mice to investigate peripheral and central components of methylglyoxal (MG)-transient receptor potential ankyrin 1 (TRPA1)-adenylyl cyclase 1 isoform (AC1) pathway

안전성 정보

• 픽토그램: GHS08,GHS05,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H290,H317,H318,H341
• 예방조치 성명서: P202 - P234 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Eye Dam. 1 - Met. Corr. 1 - Muta. 2 - Skin Sens. 1
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter