L7795

Levocetirizine dihydrochloride

≥98% (HPLC)

• 동의어(들): Levocetirizine dihydrochloride, (-)-Cetirizine dihydrochloride; 2-[2-[4-[(R)-(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid dihydrochloride
• 실험식(Hill 표기법): C₂₁H₂₅ClN₂O₃·2HCl
• CAS Number: 130018-87-0
• Molecular Weight: 461.81
• MDL number: MFCD07366507
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329817657
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• solubility: H₂O: ≥23 mg/mL
• 저장 온도: room temp
• SMILES string: Cl.Cl.OC(=O)COCCN1CCN(CC1)[C@H](c2ccccc2)c3ccc(Cl)cc3
• InChI: 1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H/t21-;;/m1../s1
• InChI key: PGLIUCLTXOYQMV-GHVWMZMZSA-N
• 유전자 정보: human ... HRH1(3269)

설명

일반 설명

Levocetirizine dihydrochloride is the R-enantiomer of cetirizine and is used for treating seasonal allergic rhinitis and chronic idiopathic urticaria. The liver metabolizes 14% of levocetirizine and rest is excreted in urine.[1] The response of levocetirizine to histamine is comparatively higher to cetirizine.[2]

애플리케이션

Levocetirizine dihydrochloride has been used as standard in the thin layer chromatography optimization[3] and in preparation of racemic cetirizine standard for subcritical fluid chromatography-tandem mass spectrometry analysis.[4]

생화학적/생리학적 작용

Levocetirizine dihydrochloride is a nonsedating type histamine H1-receptor antagonist; active isomer of cetirizine

Levocetirizine hydrochloride is a nonsedating antihistamine. It is a histamine H1-receptor antagonist, the active isomer of cetirizine. Levocetirizine has high bioavailability, high affinity for and occupancy of the H1 receptor.

특징 및 장점

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• 픽토그램: GHS07,GHS09
• 신호어: Warning
• 유해 및 위험 성명서: H302,H400
• 예방조치 성명서: P273 - P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable