추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
white to beige
solubility
DMSO: ≥20 mg/mL
ethanol: 24 mg/mL
H2O: insoluble
저장 온도
room temp
SMILES string
OC1(CCN(CC1)Cc2c[nH]c3ccccc23)c4ccc(Cl)cc4
InChI
1S/C20H21ClN2O/c21-17-7-5-16(6-8-17)20(24)9-11-23(12-10-20)14-15-13-22-19-4-2-1-3-18(15)19/h1-8,13,22,24H,9-12,14H2
InChI key
LLBLNMUONVVVPG-UHFFFAOYSA-N
유전자 정보
human ... DRD2(1813) , DRD3(1814) , DRD4(1815)
관련 카테고리
애플리케이션
L-741,626 has been used as selective dopamine (D2) receptor antagonist to study its effects on the uptake of dopamine in human embryonic kidney 293 (HEK293) cells.[1] It has also been used as a D2 receptor antagonist to study its effects on thyrotropin-releasing hormone (TRH) induced prolactin release.[2]
생화학적/생리학적 작용
L-741,626 is a selective dopamine (D2) receptor antagonist.[3]
특징 및 장점
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
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시험 성적서(COA)
Lot/Batch Number
Florence Loiseau et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 19(1), 23-33 (2008-09-17)
Though D(3) receptor antagonists can enhance cognitive function, their sites of action remain unexplored. This issue was addressed employing a model of social recognition in rats, and the actions of D(3) antagonists were compared to D(1) agonists that likewise possess
Masaki Nakano et al.
General and comparative endocrinology, 168(2), 287-292 (2010-06-18)
Dopamine receptors in mammals are known to consist of two D1-like receptors (D1 and D5) and three D2-like receptors (D2, D3 and D4). The aim of this study was to determine the dopamine receptor subtype that mediates the inhibitory action
Alexander Gont et al.
Oncotarget, 8(5), 8559-8573 (2017-01-05)
A defining feature of the brain cancer glioblastoma is its highly invasive nature. When glioblastoma cells are isolated from patients using serum free conditions, they accurately recapitulate this invasive behaviour in animal models. The Rac subclass of Rho GTPases has
Gregory T Collins et al.
The Journal of pharmacology and experimental therapeutics, 325(2), 691-697 (2008-02-29)
Food restriction enhances sensitivity to the reinforcing effects of a variety of drugs of abuse including opiates, nicotine, and psychostimulants. Food restriction has also been shown to alter a variety of behavioral and pharmacological responses to dopaminergic agonists, including an
David J G Watson et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 37(3), 770-786 (2011-10-28)
Dopamine D(3) receptor antagonists exert pro-cognitive effects in both rodents and primates. Accordingly, this study compared the roles of dopamine D(3) vs D(2) receptors in social novelty discrimination (SND), which relies on olfactory cues, and novel object recognition (NOR), a
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