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Merck
모든 사진(1)

문서

J4252

Sigma-Aldrich

JWH-015

≥98% (HPLC), powder

동의어(들):

(2-Methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C23H21NO
CAS Number:
155471-08-2
Molecular Weight:
327.42
MDL number:
MFCD02094630
UNSPSC 코드:
12352200
PubChem Substance ID:
24278502
NACRES:
NA.77

분석

≥98% (HPLC)

형태

powder

약물 제어

regulated under CDSA - not available from Sigma-Aldrich Canada

색상

off-white

solubility

DMSO: >20 mg/mL (with heating)

저장 온도

−20°C

SMILES string

CCCn1c(C)c(C(=O)c2cccc3ccccc23)c4ccccc14

InChI

1S/C23H21NO/c1-3-15-24-16(2)22(20-12-6-7-14-21(20)24)23(25)19-13-8-10-17-9-4-5-11-18(17)19/h4-14H,3,15H2,1-2H3

InChI key

LJSBBBWQTLXQEN-UHFFFAOYSA-N

유전자 정보

human ... CNR2(1269)
rat ... Cnr1(25248)

애플리케이션

JWH-015 has been used to study its effect on tumor-evoked pain behavior. It has also been used to study its protective effects on rat brain mitochondria upon paraquat exposure.

생화학적/생리학적 작용

JWH-015 is a selective CB2 cannabinoid receptor agonist. JWH-015 is structurally classified as naphthoylindoles.

특징 및 장점

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves

시험 성적서(COA)

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문서 라이브러리 방문

Chao Li et al.
Neuroscience letters, 707, 134286-134286 (2019-06-01)
The cannabinoid receptor 2 (CB2R) has been considered as a potential therapeutic target to ameliorate the neuroinflammation and cognitive impairments of Alzheimer's disease (AD). However, there has been little research on the diverse roles of CB2R in regulating different forms
J W Huffman
Current pharmaceutical design, 6(13), 1323-1337 (2000-07-21)
Following the identification of the CB2 receptor several groups explored the development of selective ligands for this receptor which occurs principally in the periphery. This led to the discovery that two cannabimimetic indoles, 1-(2, 3-dichlorobenzoyl)-2-methyl-3-(2-[1-morpholino]ethyl)-5-methoxyind ole (L768242) and 2-methyl-1-propyl-3-(1-naphthoyl)indole (JWH-015)
Clinical Toxicology, An Issue of Emergency Medicine Clinics of North America, 4-4 (2014)
G Griffin et al.
European journal of pharmacology, 339(1), 53-61 (1998-02-05)
We have investigated whether there are cannabinoid CB2 receptors that can mediate cannabinoid-induced inhibition of electrically evoked contractions in the mouse vas deferens or guinea-pig myenteric plexus-longitudinal muscle preparation. Our results showed that mouse vas deferens and guinea-pig whole gut
Protective effects of the synthetic cannabinoids CP55, 940 and JWH-015 on rat brain mitochondria upon paraquat exposure
Velez-Pardo C, et al.
Neurochemical Research, 35(9), 1323-1332 (2010)
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문서

Synthetic Cannabinoid Analysis

A large variety of cannabinoid drug standards, along with an HPLC method with the Supelco Ascentis® Express RP-Amide column, are presented in this article.

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