H1753

Hydralazine hydrochloride

• 동의어(들): 1-Hydrazinophthalazine hydrochloride
• 실험식(Hill 표기법): C₈H₈N₄ · HCl
• CAS Number: 304-20-1
• Molecular Weight: 196.64
• EC Number: 206-151-0
• MDL number: MFCD00135998
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278461
• NACRES: NA.77

속성

• 생물학적 소스: synthetic (organic)
• 분석: ≥99% (TLC)
• 양식: powder
• mp: 273 °C
• solubility: water: 50 mg/mL
• SMILES string: Cl[H].N\N=C1/N=NC=C2C=CC=CC12
• InChI: 1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5,7H,9H2;1H/b11-8-;
• InChI key: SECXUXOCDLQOBI-MKFZHGHUSA-N
• 유전자 정보: human ... MAOA(4128) , MAOB(4129)

설명

애플리케이션

Hydralazine hydrochloride has been used:

• as a vasodilator to study its effects on hypertension in T-cell frequencies in juvenile rats[1]
• as a semicarbazide-sensitive amine oxidase (SSAO) inhibitor to study its effects on myocardial ischemia-reperfusion (I/R) injury[2]
• as a vasodilator to study its effects on insulin secretion and glucose tolerance[3]

생화학적/생리학적 작용

Hydralazine hydrochloride has therapeutic effects against heart failure and high blood pressure.[4]

Inhibits DNA methyltransferase and modulates epigenetic regulation of gene expression. Non-selective MAO-A/B inhibitor; antihypertensive; semicarbazide-sensitive amine oxidase inhibitor.

특징 및 장점

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301,H315,H319,H335
• 예방조치 성명서: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves