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추천 제품
일반 설명
Factor V, a glycoprotein is usually seen in the alpha granules of platelets and in plasma.[1]
Factor Va is the activated form of factor V and the cofactor of Xa. It is a component of the prothrombinase complex.
생화학적/생리학적 작용
Factor V is a key component in blood coagulation systems, where deficiencies can inhibit thrombin generation and affect hemostasis. It has been used in studies of coagulopathic bleeding which occurs following injury and is a leading cause of hospital deaths.
Factor Va serves as a receptor and positive effector of factor Xa. Hence it can efficiently help in the conversion of prothrombin to thrombin.[2]
결합
View this factors role in the Coagulation Cascade
단위 정의
One unit is equivalent to the Factor V activity in 1.0 mL of normal human plasma at pH 7.4 at 37 °C.
물리적 형태
Aqueous solution containing 50% (v/v) glycerol and 5mM CaCl2
면책조항
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Less Common Congenital Disorders of Hemostasis
Consultative Hemostasis and Thrombosis, 60-78 (2013)
The factor V activation paradox
Orfeo T, et al.
The Journal of Biological Chemistry, 279(19), 19580-19591 (2004)
Eliza A Ruben et al.
Blood, 139(24), 3463-3473 (2022-04-16)
The intrinsic and extrinsic pathways of the coagulation cascade converge to a common step where the prothrombinase complex, comprising the enzyme factor Xa (fXa), the cofactor fVa, Ca2+ and phospholipids, activates the zymogen prothrombin to the protease thrombin. The reaction
Eliza A Ruben et al.
Blood, 137(22), 3137-3144 (2021-03-09)
Coagulation factor V (fV) is the precursor of fVa, which, together with fXa, Ca2+, and phospholipids, defines the prothrombinase complex and activates prothrombin in the penultimate step of the coagulation cascade. We solved the cryogenic electron microscopy (cryo-EM) structures of
Sandro B Rizoli et al.
The Journal of trauma, 71(5 Suppl 1), S427-S434 (2011-12-17)
Coagulopathic bleeding is a leading cause of in-hospital death after injury. A recently proposed transfusion strategy calls for early and aggressive frozen plasma transfusion to bleeding trauma patients, thus addressing trauma-associated coagulopathy (TAC) by transfusing clotting factors (CFs). This strategy
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