추천 제품
분석
≥98% (HPLC)
형태
powder
색상
yellow
solubility
DMSO: >20 mg/mL
저장 온도
2-8°C
SMILES string
COc1cc(ccc1O)\C=N\Nc2ncnc3sc4CCCCc4c23
InChI
1S/C18H18N4O2S/c1-24-14-8-11(6-7-13(14)23)9-21-22-17-16-12-4-2-3-5-15(12)25-18(16)20-10-19-17/h6-10,23H,2-5H2,1H3,(H,19,20,22)/b21-9+
InChI key
VFNUTEMVQGLDAG-ZVBGSRNCSA-N
생화학적/생리학적 작용
Exo2 acts as a chemical probe of intracellular transport. Edxo2 has activities similar to Brefeldin A with membrane trafficking to the Golgi appartus, but appears more selective.
Exo2 is a bioactive small molecule that activates Golgi-endoplasmic reticulum (ER) fusion in mammals by distorting the Golgi apparatus. It prevents the release of secretory cargo from the ER. Exo2 do not modify the morphology of the trans-Golgi network (TGN). It also inhibits the anterograde movement of vesicular stomatitis virus G (VSV G) glycoprotein, from ER to Golgi.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
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The Plant cell, 31(10), 2315-2331 (2019-08-24)
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Combined targeting of Arf1 and Ras potentiates anticancer activity for prostate cancer therapeutics.
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Journal of experimental & clinical cancer research : CR, 36(1), 112-112 (2017-08-24)
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The Biochemical journal, 414(3), 471-484 (2008-06-05)
The small-molecule inhibitor Exo2 {4-hydroxy-3-methoxy-(5,6,7,8-tetrahydrol[1]benzothieno[2,3-d]pyrimidin-4-yl)hydraz-one benzaldehyde} has been reported to disrupt the Golgi apparatus completely and to stimulate Golgi-ER (endoplasmic reticulum) fusion in mammalian cells, akin to the well-characterized fungal toxin BFA (brefeldin A). It has also been reported that
Gertrud Wiedemann et al.
The Plant cell, 30(3), 717-736 (2018-03-09)
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