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Merck
모든 사진(1)

주요 문서

E8280

Sigma-Aldrich

Exo 1

≥98% (HPLC), solid

동의어(들):

2-(4-Fluorobenzoylamino)benzoic acid methyl ester, 2-(4-Fluorobenzoylamino)methylbenzoate

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5 MG
₩108,808
25 MG
₩312,925

₩108,808


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크기 선택

보기 변경
5 MG
₩108,808
25 MG
₩312,925

About This Item

실험식(Hill 표기법):
C15H12NFO3
CAS Number:
Molecular Weight:
273.26
MDL number:
UNSPSC 코드:
12352203
PubChem Substance ID:
NACRES:
NA.77

₩108,808


구입 가능 여부는 고객센터에 문의하십시오.
기존과 동일한 품질을 인하된 가격으로 - 어려운 예산 상황을 머크와 함께 극복하세요

벌크 견적 요청

Quality Level

분석

≥98% (HPLC)

양식

solid

solubility

DMSO: soluble 19 mg/mL

SMILES string

COC(=O)c1ccccc1NC(=O)c2ccc(F)cc2

InChI

1S/C15H12FNO3/c1-20-15(19)12-4-2-3-5-13(12)17-14(18)10-6-8-11(16)9-7-10/h2-9H,1H3,(H,17,18)

InChI key

KIAPWMKFHIKQOZ-UHFFFAOYSA-N

애플리케이션

Exo 1 has been used as a component of the BRB80 buffer to study coat protein 1 (COPI)-mediated membrane trafficking.[1] It has also been used as a Golgi inhibitor to study its effects on the long interspersed nuclear element-1 (L1) retrotransposition.[2]

생화학적/생리학적 작용

Exo 1 is a cell-permeable methylanthranilate analog that promotes the release of adenosine diphosphate (ADP)-ribosylation factor (ARF) 1 from Golgi membranes.[3] It also inhibits the membrane trafficking between the endoplasmic reticulum (ER) and the Golgi bodies.[4]
Reversible inhibitor of exocytosis; Golgi ARF 1 (ADP-Ribosylation Factor) GTPase activator.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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이미 열람한 고객

Yan Feng et al.
Proceedings of the National Academy of Sciences of the United States of America, 100(11), 6469-6474 (2003-05-10)
A phenotypic screen was used to search for drug-like molecules that can interfere with specific steps in membrane traffic. 2-(4-Fluorobenzoylamino)-benzoic acid methyl ester (Exo1), identified in this screen, induces a rapid collapse of the Golgi to the endoplasmic reticulum, thus
ALan F Rees et al.
Marine biology, 164(2), 30-30 (2017-01-31)
Many marine megavertebrate taxa, including sea turtles, disperse widely from their hatching or birthing locations but display natal homing as adults. We used flipper tagging, satellite tracking and genetics to identify the origin of loggerhead turtles living in Amvrakikos Gulf
Philip J Lester et al.
Scientific reports, 10(1), 12398-12398 (2020-07-28)
CRISPR gene drives have potential for widespread and cost-efficient pest control, but are highly controversial. We examined a potential gene drive targeting spermatogenesis to control the invasive common wasp (Vespula vulgaris) in New Zealand. Vespula wasps are haplodiploid. Their life
Justin Chun et al.
Molecular biology of the cell, 19(8), 3488-3500 (2008-06-06)
Despite extensive work on ADP-ribosylation factor (Arf) 1 at the Golgi complex, the functions of Arf2-5 in the secretory pathway, or for that of any Arf at the ER-Golgi intermediate compartment (ERGIC) remain uncharacterized. Here, we examined the recruitment of
Time-lapse observation of chromosomes, cytoskeletons and cell organelles during male meiotic divisions in Drosophila
Tanabe K, et al.
Bio-protocol, 7, e2225-e2225 (2017)

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