D8168

Anti-Dystrophin Antibody

mouse monoclonal, MANDYS8

• 동의어(들): Dystrophin Antibody, Dystrophin Antibody - Monoclonal Anti-Dystrophin antibody produced in mouse
• MDL number: MFCD00164586
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 제품명: Monoclonal Anti-Dystrophin antibody produced in mouse, clone MANDYS8, ascites fluid
• 생물학적 소스: mouse
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: ascites fluid
• 항체 생산 유형: primary antibodies
• 클론: MANDYS8, monoclonal
• 종 반응성: chicken, rat, human, pig, rabbit, mouse
• 기술: indirect ELISA: suitable; indirect immunofluorescence: 1:400 using frozen human or animal muscle tissue sections.; microarray: suitable; western blot: suitable
• 동형: IgG2b
• UniProt 수납 번호: P11532
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... DMD(1756) ; mouse ... Dmd(13405) ; rat ... Dmd(24907)

설명

일반 설명

Monoclonal Anti-Dystrophin (mouse IgG2b isotype) is derived from the MANDYS8 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Dystrophin is a structural protein on the inner face of the membrane, consisting of a 25-repeat, rod-like, triple-helical domain separating an N-terminal actin binding domain from two C-terminal domains, one of which is rich in cysteine.

면역원

recombinant human dystrophin fragment.

애플리케이션

Monoclonal Anti-Dystrophin antibody produced in mouse has been used in

• immunohistochemistry
• immunofluorescence[1]
• double immunofluorescence terminal dUTP nick-end labeling (TUNEL)[1]
• immunoblotting

Monoclonal anti-dystrophin antibody can be used for localization of dystrophin using immunochemical assays like ELISA and immunohistochemistry. The antibody can also be used in immunoblotting for brain dystrophin. Further, it can be used in western blotting and double immunofluorescent labelling (diluted 1: 500) of dystrophin.

생화학적/생리학적 작용

Dystrophin deficiency is associated with severe Duchenne muscular dystrophy (DMD). Becker muscular dystrophy (BMD) show less pronounced abnormalities of dystrophin protein expression. Since abnormalities in the protein expression occur specifically in patients with these types of muscular dystrophy, dystrophin analysis may be used to distinguish these conditions from other neuromuscular diseases.

표적 설명

The rod domain of the human dystrophin molecule is present in normal muscle tissue and in nearly all Becker muscular dystrophies. It is absent in the cases of Duchenne muscular dystrophies and in the dystrophic mouse (mdx).

기타 정보

This product can be found as purified product that was produced using cell culture hybridoma product.
SAB4200764 Anti-Dystrophin antibody, Mouse monoclonal
clone MANDYS8, purified from hybridoma cell culture

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable