C9873

CPTH2

≥98% (HPLC), powder

• 동의어(들): Cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl)hydrazone
• 실험식(Hill 표기법): C₁₄H₁₄ClN₃S
• CAS Number: 357649-93-5
• Molecular Weight: 291.80
• MDL number: MFCD02307488
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329775211
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: >10 mg/mL
• 저장 온도: 2-8°C
• SMILES string: Clc1ccc(cc1)-c2csc(N\N=C3\CCCC3)n2
• InChI: 1S/C14H14ClN3S/c15-11-7-5-10(6-8-11)13-9-19-14(16-13)18-17-12-3-1-2-4-12/h5-9H,1-4H2,(H,16,18)
• InChI key: YYTHPXHGWSAKIZ-UHFFFAOYSA-N

설명

일반 설명

CPTH2 ((3-methylcyclopentylidene-[4-(4′-chlorophenyl)thiazol-2-yl]hydrazone)) inhibits histone acetyltransferase functionality and reduces acetylation of histone H3 [1] and H4.[2] CPTH2 promotes apoptosis in lymphoma cell lines.[2] It may serve as an anticancer agent. CPTH2 inhibits α-tubulin acetylation and modulates autophagic pathway in human acute myeloid leukemia cell lines.[3]

애플리케이션

CPTH2 has been used for the inhibition of histone acetyltransferase in cortical cultures,[4] bud cells[5] and natural killer T cells (iNKT).[6]

생화학적/생리학적 작용

CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating the Gcn5 network.

CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating the Gcn5 network. Histone Acetyltransferase (HAT) inhibitor modulating Gcn5 network. Histone acetyltransferases (HATs) act as transcriptional coactivators. Histone acetylation plays an important role in regulating the chromatin structure and is tightly regulated by two classes of enzyme, histone acetyltransferases (HAT) and histone deacetylases (HDAC). Deregulated HAT and HDAC activity plays a role in the development of a range of cancers. Consequently, inhibitors of these enzymes have potential as anticancer agents.

특징 및 장점

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안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable