C2917

Corticotropin Releasing Factor Antagonist

≥97% (HPLC)

• 동의어(들): α-Helical CRF (9-41), α-Helical corticotropin releasing factor fragment (9-41)
• 실험식(Hill 표기법): C₁₆₆H₂₇₄N₄₆O₅₃S₂
• CAS Number: 99658-03-4
• Molecular Weight: 3826.36
• MDL number: MFCD00081543
• UNSPSC 코드: 51111800
• NACRES: NA.32

속성

• Quality Level: 200
• 분석: ≥97% (HPLC)
• 양식: powder
• 저장 온도: −20°C
• 유전자 정보: human ... CRH(1392) ; mouse ... CRH(12918) ; rat ... CRH(81648)

설명

Amino Acid Sequence

Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Met-Leu-Glu-Met-Ala-Lys-Ala-Glu-Gln-Glu-Ala-Glu-Gln-Ala-Ala-Leu-Asn-Arg-Leu-Leu-Leu-Glu-Glu-Ala-NH2

생화학적/생리학적 작용

Exhibits 10-fold higher affinity for rat CRF_2α receptors over human CRF_2α receptors.

The corticotropin releasing factor (CRF) antagonist α-helical CRF [9-41] exhibits 10-fold higher affinity for rat CRF_2α receptors over human CRF_2α receptors. It has been used to elucidate the role of CRF in various physiological systems. In colonic epithelium, it abolishes CRF-induced changes in ion secretion, and significantly inhibits CRF-stimulated conductance. It antagonizes the CRF-induced proinflammatory degranulation of perivascular mast cells that are activated in response to acute psychological stress and CRF secretion.

기타 정보

Lyophilized from 0.1% TFA in H2O

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)